Citalopram hydrobromide Basic information

Abstract Efficacy Side effects References

Product Name: Citalopram hydrobromide

Synonyms: 1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobromi;Citalopram hydrobromide solution;Citalopram HBr Salt;1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobr;1-[3-(DIMETHYLAMINO)PROPYL]-1-(4-FLUOROPHENYL)-1,3-DIHYDRO-5-ISOBENZOFURANCARBONITRILE HYDROBROMIDE;5-ISOBENZOFURANCARBONITRILE, 1,3-DIHYDRO-1-(3-(DIMETHYLAMINO)PROPYL)-1-(4-FLUOROPHENYL)-;CITALOPRAM HBR;(+/-)-CITALOPRAM HYDROBROMIDE

CAS: 59729-32-7

MF: C20H22BrFN2O

MW: 405.3

EINECS: 261-890-6

Product Categories: Other APIs;Heterocyclic Compounds;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Citalopram;Serotonin;APIs;Neurochemicals,Pharmaceuticals;Pharmaceutical intermdiate

Mol File: 59729-32-7.mol

Citalopram hydrobromide Structure

Citalopram hydrobromide Chemical Properties

Melting point 182-188°C

Fp 9℃

storage temp. -20°C Freezer

solubility H2O: soluble (sparingly)

Stability: Stable. Incompatible with strong oxidizing agents.

CAS DataBase Reference 59729-32-7(CAS DataBase Reference)

Safety Information

Hazard Codes F,T

Risk Statements 11-23/24/25-39/23/24/25-22

Safety Statements 7-16-36/37-45-24/25

RIDADR 3249

RTECS NP6313500

HazardClass 6.1(b)

PackingGroup III

HS Code 29329990

Hazardous Substances Data 59729-32-7(Hazardous Substances Data)

MSDS Information

Citalopram hydrobromide Usage And Synthesis

Abstract Citalopram hydrobromide (citalopram HBr) is an orally administered selective serotonin reuptake inhibitor (SSRI) with a chemical structure unrelated to that of other SSRIs or of tricyclic, tetracyclic, or other available antidepressant agents. 

Citalopram HBr occurs as a fine, white to off-white powder. Citalopram HBr is sparingly soluble in water and soluble in ethanol.

The tablet is available as the brand-name drug Celexa. In Australia, the UK, Germany, Portugal, Poland, and most European countries, it is licensed for depressive episodes and panic disorder with or without agoraphobia. In Spain, it is also used for obsessive-compulsive disorder.

Efficacy The advantage of this drug is that it has no effect on cholinergic muscarinic receptors, histamine receptors and α-adrenergic receptors . Because if these receptors are inhibited,  a lot of side effects caused by antidepressants will produce, such as dry mouth, sedation, orthostatic hypotension. Citalopram hydrobromide is effective for not only endogenous depression patients but also non-endogenous depression patients. Its antidepressant effect is usually established after 2-4 weeks . Citalopram hydrobromide does not affect the cardiac conduction system and blood pressure, which is particularly important for elderly patients. In addition, citalopram hydrobromide does not affect the blood, liver and kidney systems. Rare side effects and the most mild sedative properties make it particularly suitable for long-term treatment.It does not lead to weight gaining,and it does not strengthen the role of alcohol.

Side effects You should not use this medicine if you are allergic to citalopram or escitalopram (Lexapro), or if you also take pimozide.

Do not use citalopram if you have used an monoamine oxidase inhibitor (MAOI) in the past 14 days. A dangerous drug interaction could occur. MAOI inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Side effects are usually small, very mild and transient. The most common adverse reactions are: nausea, increased sweating, salivation reduction, headaches and sleep time shortening. They are usually more obvious in the first or second week when treatment begins, and they generally disappear with the improvement of depression. In rare cases ,seizures have been observed. For  patients who suffer bradycardia , bradycardia can make treatment more complicated.

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Chemical Properties White Crystalline Powder

Uses Antidepressant;5HT uptake inhibitor

Uses Anti-depressant/Anti-psychotic

Uses An inhibitor of serotonin (5-HT) uptake. Used as an antidepressant

Citalopram hydrobromide Preparation Products And Raw materials