Factory price PLX4032 CAS 918504-65-1 in stock

Our main business covers the fields below:

 

1.Noble Metal Catalysts (Pt.Pd...)

2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)

3.OLED intermediates (Fluorene,Carbazole,Boric acid...)

4.Pharmaceutical intermediates 

 

 About us

1.More than 10 years chemical exporting experience 

We have produced chemical more than fifteen years., 80% products are for export .

More than 10 years chemical exporting experience. Good and stabilized factory price.

2.Strict quality control system

3.Supply sample

Before order , we can send the sample for your testing . We ensure the quality is the same as bulk quantity .

 

 Our advantage:

Q1:Can I get the free sample

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

 

Q2: How to start orders or make payments

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Payment by T/T, or Paypal or L/C.

 

Q3: How to confirm the Product Quality before placing orders

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.

You can send us your product specifications and requests,we will manufacture the products according to your requests.

 

Q4:What’s your MOQ

A:Usually according you demand.

 

Q5: How about delivery leadtime

A:Delivery lead time: As soon as possible. (Chinese holiday not included)

 

Q6:Is there a discount

A:Different quantity has different discount.

 

Q7: How to contact us

A:You can chat with us by Trademanager,Email,WhatsAPP,Wechat.

You can choose your interested products and send inquiry to us.

You can dial our telephone directly, you will get our reply.

 

High purity CAS 665-66-7 1-Adamantanamine hydrochloride in stock

Our main business covers the fields below:

 

1.Noble Metal Catalysts (Pt.Pd...)

2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)

3.OLED intermediates (Fluorene,Carbazole,Boric acid...)

4.Pharmaceutical intermediates 

 

 About us

1.More than 10 years chemical exporting experience 

We have produced chemical more than fifteen years., 80% products are for export .

More than 10 years chemical exporting experience. Good and stabilized factory price.

2.Strict quality control system

3.Supply sample

Before order , we can send the sample for your testing . We ensure the quality is the same as bulk quantity .

 

 Our advantage:

Q1:Can I get the free sample

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

 

Q2: How to start orders or make payments

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Payment by T/T, or Paypal or L/C.

 

Q3: How to confirm the Product Quality before placing orders

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.

You can send us your product specifications and requests,we will manufacture the products according to your requests.

 

Q4:What’s your MOQ

A:Usually according you demand.

 

Q5: How about delivery leadtime

A:Delivery lead time: As soon as possible. (Chinese holiday not included)

 

Q6:Is there a discount

A:Different quantity has different discount.

 

Q7: How to contact us

A:You can chat with us by Trademanager,Email,WhatsAPP,Wechat.

You can choose your interested products and send inquiry to us.

You can dial our telephone directly, you will get our reply.

Factory price PLX4032 CAS 918504-65-1 in stock

Details

PLX4032 Basic information
Product Name:    PLX4032
Synonyms:    N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide;PLX4032 (VeMurafenib);PLX4032, RG7204, ZELBORAF, RO5185426;R7204;N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaM;PLX4032, R7204, RG7204, RO5185426;VeMurafenib (PLX4032, RG7204);N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide Vemurafenib PLX 4032
CAS:    918504-65-1
MF:    C23H18ClF2N3O3S
MW:    489.92
EINECS:    
Product Categories:    API;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;Sulfur & Selenium Compounds;Aromatics;Inhibitor;RG7204;Antineoplastic;Inhibitors;MAPK
Mol File:    918504-65-1.mol
PLX4032 Structure
PLX4032 Chemical Properties
density     1.46
storage temp.     -20°C
solubility     Soluble in DMSO (up to 100 mg/ml)
form     White powder.
pka    6.26±0.10(Predicted)
color     White or off-white
Stability:    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference    918504-65-1
Safety Information
HS Code     29339900
Hazardous Substances Data    918504-65-1(Hazardous Substances Data)
MSDS Information
PLX4032 Usage And Synthesis
Description    In August 2011, the United States FDA approved vemurafenib (PLX- 4032, RO-5185426) for the treatment of patients with metastatic melanoma with the BRAFV600E mutation. Vemurafenib has been developed as a targeted therapy for patients with the BRAF gene mutation since oncogenic B-raf signaling is implicated in approximately 50% of melanomas. Vemurafenib was identified based on an initial high-throughput screen followed by the extensive use of structure-based drug design. Vemurafenib is a potent inhibitor of B-RafV600E kinase (IC50=13 nM) compared to its potency against wildtype B-raf (IC50=160 nM) and is fairly selective versus a panel of 200 kinases. It does inhibit other kinases (RAF1, SRMS, ACK1, MAP4K5, and FGR) and mutant B-raf kinases (BRAFV600K, BRAFV600D, and BRAFV600R) with enzyme IC50's of <100 nM.
Chemical Properties    Off-White Solid
Originator    Plexxikon (United States)
Uses    Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600.
Uses    Vemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM
Uses    PLX4032 is an orally bioavailable, ATP-competitive inhibitor of mutant V600E and wild type B-Raf kinases (IC50s = 31 and 100 nM, respectively). It inhibits cell proliferation in a variety of cell lines expressing B-Raf V600E and synergizes strongly with taxol, vinblastine, and oxaliplatin in inhibiting the proliferation of B-RafV600E transformed cancer cells. PLX4032 is effective against the growth of tumors bearing the B-Raf V600E mutation.[Cayman Chemical]
Definition    ChEBI: A pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone ormal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases.

Packing:

About us

1.More than 10 years chemical exporting experience 

We have produced chemical more than fifteen years., 80% products are for export .

More than 10 years chemical exporting experience. Good and stabilized factory price.

2.Strict quality control system

3.Supply sample

Before order , we can send the sample for your testing . We ensure the quality is the same as bulk quantity .

 

Delivery:

 

 Our advantage:

Q1:Can I get the free sample

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

 

Q2: How to start orders or make payments

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Payment by T/T, or Paypal or L/C.

 

Q3: How to confirm the Product Quality before placing orders

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.

You can send us your product specifications and requests,we will manufacture the products according to your requests.

 

Q4:What’s your MOQ

A:Usually according you demand.

 

Q5: How about delivery leadtime

A:Delivery lead time: As soon as possible. (Chinese holiday not included)

 

Q6:Is there a discount

A:Different quantity has different discount.

 

Q7: How to contact us

A:You can chat with us by Trademanager,Email,WhatsAPP,Wechat.

You can choose your interested products and send inquiry to us.

You can dial our telephone directly, you will get our reply.

 

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