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TIANFU-CHEM - 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide CAS NO.912444-00-9
- FOB Price: USD: 1,000.00-1,000.00 /Kilogram Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: L/C,D/A,D/P,T/T,MoneyGram,Other
- Available Specifications:
1(1-100)Kilogram
- Product Details
Keywords
- 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide
- 912444-00-9
- C13H16N4O.2ClH
Quick Details
- ProName: TIANFU-CHEM - 2-[(2R)-2-Methylpyrroli...
- CasNo: 912444-00-9
- Molecular Formula: C13H16N4O.2ClH
- Appearance: Solid
- Application: Organic synthesis
- DeliveryTime: PROMPT
- PackAge: IN 25kg drums
- Port: SHANGHAI
- ProductionCapacity: 10 Metric Ton/Month
- Purity: 99.0%
- Storage: In Room Temperature
- Transportation: As per MSDS
- LimitNum: 1 Gram
- Heavy metal: N/A
- Grade: Industrial Grade,Food Grade,Pharma Gra...
Superiority
Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license.
We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the company is to put quality first and put our customer’s needs first - the satisfaction of our customers is the company's ultimate goal.
Improving product quality and service level is our responsibility, and creating more value for our customer’s is our purpose. We are constantly striving to make Henan Tianfu a leading chemical supplier, and hope to create a better future with you.
Details
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide Basic information
Abstract Biological activity In vitro In vivo Features References
Product Name: 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide
Synonyms: 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide;1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)-;2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide;A861695;2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide;Veliparib;ABT-888,Veliparib;Veliparib(chiral)
CAS: 912444-00-9
MF: C13H16N4O.2ClH
MW: 317.218
EINECS:
Product Categories: Amines;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitor;PARP
Mol File: 912444-00-9.mol
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-
carboxamide Structure
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide Chemical Properties
density 1.274
Safety Information
MSDS Information
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide Usage And Synthesis
Abstract Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments.
Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer.
Biological activity Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
In vitro Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor，which inhibits PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays，respectively.ABT-888 reduces clonogenic survival and inhibits DNA repair in H460 cells. ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells.
In vivo ABT-888 inhibits PARP in B16F10 and 9L xenograft models, thus enhancing the anticancer activity of temozolomide. The Combined with other cytotoxic agents, ABT-888 shows strong antitumor effect in MX-1 xenograft model. ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg according to the the size of tumors in A375 and Colo829 xenograft models.
Features ABT-888 enhances the effectiveness of common cancer treatments, such as radiation therapy and alkylating agents.
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Chemical Properties Off-White Solid
Uses ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.
Definition ChEBI: A benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor.
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide Preparation Products And Raw materials