Ciprofloxacin hydrochloride

Melting point> 300 ° C

CAS database 86483-48-9 (CAS DataBase Reference)

Ciprofloxacin Hydrochloride Use and Synthesis

Chemical properties White or slightly yellow crystalline powder. Melting point 255-257 ° C (decomposition).

Use of the goods is quinolone antibacterial one of the outstanding representatives of the German Bayer pharmaceutical factory in 1983 successfully developed quinolone antibacterial agent of the first generation of nalidixic acid as the representative of the second generation of pipiic acid as the representative, The third generation is represented by norfloxacin. Ciprofloxacin has broad antibacterial activity and strong antibacterial activity. It is effective against Gram-positive bacteria and Gram-negative bacteria. It is also effective for Pseudomonas aeruginosa and has less adverse reactions. Is the international market sales of large varieties of drugs, the rapid development of domestic production.

Use of broad-spectrum antimicrobial agents, suitable for re-mixed infection, mainly for chronic respiratory tract, E. coli drugs, infectious rhinitis, poultry cholera, avian typhoid

Production method 3-chloro-4-fluoroaniline diazotization, replacement, the formation of 2,4-dichlorofluorobenzene, and then acetylated 2,4-dichloro-5-fluoroacetophenone, with carbonic acid Diethyl ester, 2,4-dichloro-5-fluorobenzoylacetate was prepared and reacted stepwise with triethyl orthoformate, acetic anhydride and cyclopropylamine to give 2- (3,4-dichloro- 5-fluorobenzoyl) -3-cyclopropylideneacrylate, which was reacted with NaH in anhydrous dioxane and refluxed for 2 h to give 1-cyclopropyl-7-chloro-6-fluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid, followed by reaction with piperazine.

Henan Tianfu Chemical Co., Ltd is a high-tech enterprise, specializing in pharmaceutical intermediates, located in Zhengzhou High-tech Development Zone. We passed ISO 9001:2008 ub 2009, and won "High-tech Enterprise" by provincial government in 2013. Tianfu specializes in manufacuturing intermediates in areas such as Antitumor, Cardiocascular, central nervous system, diabetes, etc. Tianfu have established an efficient quality control system, owing standardization workshop. Also corportaes with Zhengzhou University, Henan University to establish an innovation practice base to omprove the innovatin ability.

 

Tianfu always adheres to the principle of "Live on High Quality" and puts the customer's interests first. Tianfu products have been exported to Europe and the United States, Japan, Korea, India and Latin America markets. Look forward to the future, Tianfu will keep improving the innovation ability to offer better products and service for more and more customers.