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Product Name: Mifepristone
Synonyms: 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-9-dien-3-one;11beta-[4-(n,n-dimethylamino)phenyl]-17alpha-(prop-1-ynyl)-delta4,9-estradiene;17-beta)-(11-bet;17beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-(11bet;17-beta-hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oest;-17beta-ol-3-one;4,9-dien-3-one;r38486
CAS: 84371-65-3
MF: C29H35NO2
MW: 429.59
EINECS:
Product Categories: Steroids;Hormone;Acetylenes;Biochemistry;Functionalized Acetylenes;Hydroxyketosteroids;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Nuclear Receptors;Steroid and Hormone;API;Hormone Drugs
Mol File: 84371-65-3.mol
Mifepristone Structure
Mifepristone Chemical Properties
Melting point  195-198°C
alpha  D20 +138.5° (c = 0.5 in chloroform)
storage temp.  2-8°C
Merck  14,6186
InChIKey VKHAHZOOUSRJNA-GCNJZUOMSA-N
CAS DataBase Reference 84371-65-3(CAS DataBase Reference)
Safety Information
Hazard Codes  T
Risk Statements  60-61
Safety Statements  53-22-36/37/39-45
WGK Germany  3
RTECS  KG2955000
Hazardous Substances Data 84371-65-3(Hazardous Substances Data)

Mifepristone Usage And Synthesis
Description Mifepristone is a kind of antagonist of the progestational and glucocorticoid hormone. It is mainly used for the treatment of hypercortisolism in patients with nonpituitary cushing syndrome. During the treatment of Cushing’s syndrome, mifepristone takes effect through interfering with the binding of cortisol to its receptor. It reduces the effects of excess cortisol (e.g., high blood sugar levels) without causing decreased cortisol production. It can also be used to end a pregnancy. Its inhibition on progesterone can induce bleeding during the luteal phase and in early pregnancy. 
Chemical Properties Pale Yellow Solid
Uses glutamate uptake inhibitor, AMPA blocker
Uses A progesterone and glucocorticoid antagonist, suppresses VEGF production.
Uses A progesterone receptor antagonist with partial agonist activity. Abortifacient.
Biological Activity Selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo . Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone.