CAS 773092-05-0 Acotiamide hydrochloride trihydrate CAS NO.773092-05-0

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Product Details

Keywords

773092-05-0
Acotiamide hydrochloride trihydrate
C21H31ClN4O5S

Quick Details

ProName: CAS 773092-05-0 Acotiamide hydrochlo...
CasNo: 773092-05-0
Molecular Formula: C21H31ClN4O5S
Appearance: white powder
Application: pharma
DeliveryTime: prompt
PackAge: as clients needs
Port: Shanghai,QingdaoTianjin,Guangzhou
ProductionCapacity: 1 Metric Ton/Day
Purity: 99%
Storage: RT
Transportation: sea
LimitNum: 1 Kilogram
Moisture Content: N/A
Impurity: N/A
N/A: N/A

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Details

Acotiamide hydrochloride trihydrate Basic information

Product Name: Acotiamide hydrochloride trihydrate

Synonyms: Acotiae;4-Thiazolecarboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-,hydrochloride,hydrate(1:1:3);Acofide trihydrate;N-{2-[bis(1-methylethyl)amino]ethyl}-2-[(2-hydroxy-4,5-dimethoxyphenylcarbonyl)amino];Acotiamide HCl Hydrate;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide monohydrochloride trihydrate;Acotiamide HCl Trihydrate;N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydro

CAS: 773092-05-0

MF: C21H31ClN4O5S

MW: 487.013

EINECS: 1592732-453-0

Product Categories: Inhibitors;API

Mol File: 773092-05-0.mol

Acotiamide hydrochloride trihydrate Structure

Acotiamide hydrochloride trihydrate Chemical Properties

Safety Information

MSDS Information

Acotiamide hydrochloride trihydrate Usage And Synthesis

Description In June 2013, the Ministry of Health, Labor and Welfare in Japan approved acotiamide (also referred to as Z-338 and YM443), for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia (FD). Acotiamide enhances acetylcholine release from enteric neurons through selective muscarinic acetylcholine receptor M1, M2 antagonism, and inhibition of AChE, thereby enhancing gastric emptying and gastric accommodation. Acotiamide inhibits the acetylcholine-induced Ca2+-activated Cl-current with an IC50 of 1.8 μM in oocytes expressing muscarinic M1 receptors and in oocytes expressing muscarinic M2 receptors, acotiamide inhibited the acetylcholine-induced K+ currents with an IC50 of 10.1 μM. However, studies in conscious dogs, guinea-pig gastric muscle strips and assays with human cholinesterase indicate that acotiamide inhibits AChE with a Ki of 610 nM suggesting that acotiamide stimulates gastric motility mainly by inhibiting AChE activation. In a restraint stress-induced rat model, acotiamide significantly improved delayed gastric emptying and feeding inhibition but did not affect normal gastric emptying or feeding in intact rats. A synthetic route to acotiamide that employs pyridine hydrochloride to selectively cleave a 2-substituted methyl ether from a 2,4,5-trimethoxy benzamide intermediate, as a key step, has been reported.

Originator Zeria Pharmaceutical (Japan)

Brand name Acofide