Product Name: Hexamethylphosphoramide
Synonyms: TRIS(DIMETHYLAMINO)PHOSPHINE OXIDE;Eastman Inhibitor HPT;eastmaninhibitorhpt;ENT 50,882;ENT 50882;Hexmethylphosphoramide;HMPTA;HPT
CAS: 680-31-9
MF: C6H18N3OP
MW: 179.2
EINECS: 211-653-8
Product Categories:
Mol File: 680-31-9.mol

Hexamethylphosphoramide Chemical Properties
Melting point  7 °C(lit.)
Boiling point  230-232 °C740 mm Hg(lit.)
density  1.03 g/mL at 25 °C(lit.)
vapor density  6.18 (vs air)
vapor pressure  0.07 mm Hg ( 25 °C)
refractive index  n20/D 1.459(lit.)
Fp  222 °F
form  liquid
pka 4.69±0.70(Predicted)
color  Colorless to light yellow liquid
Odor Spicy odor (no threshold data)
Water Solubility  Miscible
FreezingPoint  7℃
Merck  14,4725
BRN  1099903
Stability: Stable. Incompatible with strong acids, strong oxidizing agents.
InChIKey GNOIPBMMFNIUFM-UHFFFAOYSA-N
CAS DataBase Reference 680-31-9(CAS DataBase Reference)
NIST Chemistry Reference N,N,N',N',N",N'-Hexamethylphosphorotriamide(680-31-9)
EPA Substance Registry System Hexamethylphosphoramide (680-31-9)
Safety Information
Hazard Codes  T
Risk Statements  45-46
Safety Statements  53-45-99
RIDADR  2810
WGK Germany  3
RTECS  TD0875000
F  8
HazardClass  6.1(b)
PackingGroup  III
HS Code  29299090
Hazardous Substances Data 680-31-9(Hazardous Substances Data)
Toxicity LD50 in male, female rats (mg/kg): 2650, 3360 orally (Gaines)

Hexamethylphosphoramide Usage And Synthesis
General description Hexamethylphosphoramide is made from the reaction of dimethylamine and phosphorus oxychloride. It has a molecular weight of 179.2, appearing as colorless or light yellow transparent liquid with slightly astringent taste. It has a relative density of 1.0253~1.0257 (20 ℃), refractive index of 1.4582~1.4589 (20 °C), the freezing point of 2~7 °C and the boiling point of 116~117 °C (1480Pa). It is soluble in polar and non-polar solvents. It is also miscible with the commonly used plasticizers such as dioctyl phthalate, dioctyl sebacate, and triphenyl phosphite in any proportion. It has a similar toxicity to phosphate. Avoid contact with skin. Its containers should be tightly sealed to prevent leakage and water absorption to be deteriorated Hexamethylphosphoramide is the light stabilizer of the PVC, enabling an excellent anti-aging properties of outdoor products with excellent weather resistance, therefore being known as highly-efficient weathering agent of PVC.
Addition of 2 to copies of this product to the PVC film can significantly improve both the weather resistance and cold resistance as well as reducing the processing temperature by 10 °C. This product can also be used as the excellent polar solvent of many kinds of polymer materials such as polyphenylene sulfide, polyurethane and polyamide for improving the resin quality, simplifying the process and reducing costs. Addition it into the ethylene-propylene rubber can improve the flexibility and oil resistance. It can also be used as a co-catalyst for the polymerization of propylene to improve the catalytic efficiency of the main catalyst.

Product Name: Hexamethylphosphoramide
Synonyms: TRIS(DIMETHYLAMINO)PHOSPHINE OXIDE;Eastman Inhibitor HPT;eastmaninhibitorhpt;ENT 50,882;ENT 50882;Hexmethylphosphoramide;HMPTA;HPT
CAS: 680-31-9
MF: C6H18N3OP
MW: 179.2
EINECS: 211-653-8
Product Categories:
Mol File: 680-31-9.mol

Hexamethylphosphoramide Chemical Properties
Melting point  7 °C(lit.)
Boiling point  230-232 °C740 mm Hg(lit.)
density  1.03 g/mL at 25 °C(lit.)
vapor density  6.18 (vs air)
vapor pressure  0.07 mm Hg ( 25 °C)
refractive index  n20/D 1.459(lit.)
Fp  222 °F
form  liquid
pka 4.69±0.70(Predicted)
color  Colorless to light yellow liquid
Odor Spicy odor (no threshold data)
Water Solubility  Miscible
FreezingPoint  7℃
Merck  14,4725
BRN  1099903
Stability: Stable. Incompatible with strong acids, strong oxidizing agents.
InChIKey GNOIPBMMFNIUFM-UHFFFAOYSA-N
CAS DataBase Reference 680-31-9(CAS DataBase Reference)
NIST Chemistry Reference N,N,N',N',N",N'-Hexamethylphosphorotriamide(680-31-9)
EPA Substance Registry System Hexamethylphosphoramide (680-31-9)
Safety Information
Hazard Codes  T
Risk Statements  45-46
Safety Statements  53-45-99
RIDADR  2810
WGK Germany  3
RTECS  TD0875000
F  8
HazardClass  6.1(b)
PackingGroup  III
HS Code  29299090
Hazardous Substances Data 680-31-9(Hazardous Substances Data)
Toxicity LD50 in male, female rats (mg/kg): 2650, 3360 orally (Gaines)

Hexamethylphosphoramide Usage And Synthesis
General description Hexamethylphosphoramide is made from the reaction of dimethylamine and phosphorus oxychloride. It has a molecular weight of 179.2, appearing as colorless or light yellow transparent liquid with slightly astringent taste. It has a relative density of 1.0253~1.0257 (20 ℃), refractive index of 1.4582~1.4589 (20 °C), the freezing point of 2~7 °C and the boiling point of 116~117 °C (1480Pa). It is soluble in polar and non-polar solvents. It is also miscible with the commonly used plasticizers such as dioctyl phthalate, dioctyl sebacate, and triphenyl phosphite in any proportion. It has a similar toxicity to phosphate. Avoid contact with skin. Its containers should be tightly sealed to prevent leakage and water absorption to be deteriorated Hexamethylphosphoramide is the light stabilizer of the PVC, enabling an excellent anti-aging properties of outdoor products with excellent weather resistance, therefore being known as highly-efficient weathering agent of PVC.
Addition of 2 to copies of this product to the PVC film can significantly improve both the weather resistance and cold resistance as well as reducing the processing temperature by 10 °C. This product can also be used as the excellent polar solvent of many kinds of polymer materials such as polyphenylene sulfide, polyurethane and polyamide for improving the resin quality, simplifying the process and reducing costs. Addition it into the ethylene-propylene rubber can improve the flexibility and oil resistance. It can also be used as a co-catalyst for the polymerization of propylene to improve the catalytic efficiency of the main catalyst.