Raltegravir CAS NO.518048-05-0

Min.Order: 1 Metric Ton
Payment Terms: L/C,D/A,D/P,T/T,MoneyGram

Product Details

Keywords

518048-05-0
Raltegravir
Raltegravir

Quick Details

ProName: Raltegravir
CasNo: 518048-05-0
Molecular Formula: C20H21FN6O5
Appearance: white powder
Application: For Pharmacy Chemicals
DeliveryTime: Prompt
PackAge: As per buyers'
Port: SHANGHAI,PORT
ProductionCapacity: 10 Metric Ton/Month
Purity: 99.0%Min
Storage: Room Temperature
Transportation: by sea,air
LimitNum: 1 Metric Ton
Heavy metal: N/M
Grade: Industrial Grade,Food Grade,Pharma Gra...
Transporttation: N/M

Superiority

Product Name:	Raltegravir
Synonyms:	Raltegravir;N-((4-Fluorophenyl)methyl)-1,6-dihydro-5-hydroxy-1-methyl-2-(1-methyl-1-(((5-methyl-1,3,4-oxadiazol-2-yl)carbonyl)amino)ethyl)-6-oxo-4-pyrimidinecarboxamide;N-(2-(4-(4-Fluorobenzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide;N-(2-(4-(4-Fluorobenzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)p;Raltegravir(R&D);Raltegravir(free base);N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(2-(2-methyl-1,3,4-oxadiazole-5-carboxamido)propan-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide;N-((4-Fluorophenyl)methyl)-1,6-dihydro-5-hydroxy-1-methyl-2-(1-methyl-1-(((5-methyl-1,3,4-oxadiazol-2-yl)carbonyl)am
CAS:	518048-05-0
MF:	C20H21FN6O5
MW:	444.42
EINECS:
Product Categories:	API;Isentress;Inhibitors
Mol File:	518048-05-0.mol

Raltegravir Chemical Properties

CAS DataBase Reference

518048-05-0(CAS DataBase Reference)

Details

Product Features

Merck's Raltegravir is the first HIV integrase strand transfer inhibitor (referred to as an integrase inhibitor). It is also known as MK-0518, which can treat human immunodeficiency virus (HIV)-1 infection combining with other antiretroviral (ARV) drugs. It slows HIV-1 infection by inhibiting the necessary HIV integrase for viral replication. When raltegravir combines with other anti-HIV drugs, it can reduce the amount of HIV in the blood, while it can increase the number of so-called CD4+ T cells that belong to white blood cells. It helps against other infections. The interaction between raltegravir and ritonavir, efavirenz, tipranavir and tenofovir indicates that there is no drug cross-resistance, and there is a synergistic effect with a variety of drugs. The most common adverse reactions are diarrhea, nausea, headache. In addition, blood tests show that the muscle enzymes abnormally increased in some of patients who taked this drug.
The above information is edited by the chemicalbook of Kui Ming.

Usage

Raltegravir (MK-0518, Isentress) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectively.