Product Name: Vinpocetine
Synonyms: 3A,16A-APOVINCAMINIC ACID ETHYL ESTER;(3A,16A)-EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;CAVINTON;ETHYL APOVINCAMIN-22-OATE;EBURNAMENINE;EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;RGH-4405;VINPOCETIN
CAS: 42971-09-5
MF: C22H26N2O2
MW: 350.45
EINECS: 256-028-0
Product Categories: Active Pharmaceutical Ingredients;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cyclic Nucleotide related;Chiral Reagents;Heterocycles;ACTONEL;Cardiovascular APIs;Vinpocetine ada@tuskwei.com whatsapp;8618031153937;Vinpocetine ada@tuskwei.com sky;18031153937@198.cn
Mol File: 42971-09-5.mol

Vinpocetine Chemical Properties
Melting point  147-153 °C dec.
alpha  D20 +114° (c = 1 in pyridine)
Boiling point  484.44°C (rough estimate)
density  1.1260 (rough estimate)
refractive index  1.6500 (estimate)
storage temp.  Store at RT
solubility  DMSO: 5 mg/mL
form  solid
pka 7.87±0.60(Predicted)
color  white
optical activity [α]/D 148.5±5.0°, c = 0.1 in chloroform
λmax 315nm(EtOH)(lit.)
Merck  14,9991
Stability: Photosensitive
InChIKey DDNCQMVWWZOMLN-IRLDBZIGSA-N
NIST Chemistry Reference Vinpocetine(42971-09-5)
Safety Information
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
WGK Germany  3
RTECS  JW4792000
HS Code  29399990
Toxicity LD50 in mice, rats (mg/kg): 534, 503 orally; 240, 133.8 i.p.; 58.7, 42.6 i.v. (Pálosi, Szporny), also reported as 161.2 mg/kg i.p. in mice (Cholnoky, Dmk)

Vinpocetine Usage And Synthesis
Cerebral Vasodilator Vinpocetine is a cerebrovascular expansion drug and has a relatively stronger function than Vincamine. It can selectively increase cerebral blood flow, enhance and improve brain oxygen supply, promote metabolism, enhance the capacity of deformation for red blood cells, reduce blood viscosity, inhibit platelet aggregation, improve tissue metabolism. Vinpocetine is mainly used in the treatment of cerebral infarction sequela, cerebral hemorrhage sequelae, cerebral arteriosclerosis, etc. It can also used in the treatment of retinal vascular sclerosis and blood vessel spasm, the elderly deafness, and dizziness.
Vinpocetine is a half synthetic Vincamine derivative, and has the similar effect with Vincamine. It has a stronger expansion function for cerebrovascular selectively. Pharmacological effects are as follows:
①Inhibit the activity of calcium dependency phosphodiesterase, increase the content of cAMP which can relax vascular smooth muscle, then relax vascular smooth muscle, and further increase cerebral blood flow.
②Enhance the capacity of deformation of red blood cells, reduce blood viscosity, inhibit platelet aggregation, and thus improve blood flow and microcirculation.
③Promote the brain tissue to absorb glucose, and promote the transformation of brain monoamine metabolism.
④Inhibit the increase of brain lactic acid during cerebral ischemia, increase the ATP content, inhibit the generation of lipid peroxide in the brain, delay the occurring of spasm caused by cerebral ischemia, have the function of improving cerebral metabolism and protecting brain.

Product Name: Vinpocetine
Synonyms: 3A,16A-APOVINCAMINIC ACID ETHYL ESTER;(3A,16A)-EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;CAVINTON;ETHYL APOVINCAMIN-22-OATE;EBURNAMENINE;EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;RGH-4405;VINPOCETIN
CAS: 42971-09-5
MF: C22H26N2O2
MW: 350.45
EINECS: 256-028-0
Product Categories: Active Pharmaceutical Ingredients;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cyclic Nucleotide related;Chiral Reagents;Heterocycles;ACTONEL;Cardiovascular APIs;Vinpocetine ada@tuskwei.com whatsapp;8618031153937;Vinpocetine ada@tuskwei.com sky;18031153937@198.cn
Mol File: 42971-09-5.mol

Vinpocetine Chemical Properties
Melting point  147-153 °C dec.
alpha  D20 +114° (c = 1 in pyridine)
Boiling point  484.44°C (rough estimate)
density  1.1260 (rough estimate)
refractive index  1.6500 (estimate)
storage temp.  Store at RT
solubility  DMSO: 5 mg/mL
form  solid
pka 7.87±0.60(Predicted)
color  white
optical activity [α]/D 148.5±5.0°, c = 0.1 in chloroform
λmax 315nm(EtOH)(lit.)
Merck  14,9991
Stability: Photosensitive
InChIKey DDNCQMVWWZOMLN-IRLDBZIGSA-N
NIST Chemistry Reference Vinpocetine(42971-09-5)
Safety Information
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
WGK Germany  3
RTECS  JW4792000
HS Code  29399990
Toxicity LD50 in mice, rats (mg/kg): 534, 503 orally; 240, 133.8 i.p.; 58.7, 42.6 i.v. (Pálosi, Szporny), also reported as 161.2 mg/kg i.p. in mice (Cholnoky, Dmk)

Vinpocetine Usage And Synthesis
Cerebral Vasodilator Vinpocetine is a cerebrovascular expansion drug and has a relatively stronger function than Vincamine. It can selectively increase cerebral blood flow, enhance and improve brain oxygen supply, promote metabolism, enhance the capacity of deformation for red blood cells, reduce blood viscosity, inhibit platelet aggregation, improve tissue metabolism. Vinpocetine is mainly used in the treatment of cerebral infarction sequela, cerebral hemorrhage sequelae, cerebral arteriosclerosis, etc. It can also used in the treatment of retinal vascular sclerosis and blood vessel spasm, the elderly deafness, and dizziness.
Vinpocetine is a half synthetic Vincamine derivative, and has the similar effect with Vincamine. It has a stronger expansion function for cerebrovascular selectively. Pharmacological effects are as follows:
①Inhibit the activity of calcium dependency phosphodiesterase, increase the content of cAMP which can relax vascular smooth muscle, then relax vascular smooth muscle, and further increase cerebral blood flow.
②Enhance the capacity of deformation of red blood cells, reduce blood viscosity, inhibit platelet aggregation, and thus improve blood flow and microcirculation.
③Promote the brain tissue to absorb glucose, and promote the transformation of brain monoamine metabolism.
④Inhibit the increase of brain lactic acid during cerebral ischemia, increase the ATP content, inhibit the generation of lipid peroxide in the brain, delay the occurring of spasm caused by cerebral ischemia, have the function of improving cerebral metabolism and protecting brain.