42924-53-8 Nabumetone CAS NO.42924-53-8
- FOB Price: USD: 230.00-230.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T
- Available Specifications:
A(10-150)Kilogram
- Product Details
Keywords
- Nabumetone 42924-53-8
- Nabumetone 42924-53-8
- Nabumetone 42924-53-8
Quick Details
- ProName: 42924-53-8 Nabumetone
- CasNo: 42924-53-8
- Molecular Formula: C15H16O2
- Appearance: Powder
- Application: Organic Chemicals
- DeliveryTime: according to client's demand quantity
- PackAge: as requested
- Port: SHANGHAI
- ProductionCapacity: 100 Metric Ton/Year
- Purity: 99%
- Storage: room temperature
- Transportation: by Sea
- LimitNum: 1 Kilogram
- Heavy metal: 0.01
- Grade: Industrial Grade,Pharma Grade
- Transportation: LCL
Superiority
Product Name: Nabumetone
Synonyms: 4-[6-(trideuteriomethoxy)-2-naphthalenyl]-2-butanone;NABUMETONE, EP STANDARD;NABUMETONE, MM(CRM STANDARD);NABUMETONE, IMP. F (EP): 6,6'-DIMETHOXY-2,2'-BINAPHTHALENYL MM(CRM STANDARD);NABUMETONE, IMPURITY D(E)-4-(6-METHOXYNAPHTHALEN-2-YL)BUT-3-EN-2-ONE EP STANDARD;NABUMETONE, USP(CRM STANDARD);NABUMETONE, BP STANDARD;NABUMETONE:4-(6-METHOXY-2-NAPHTYLBUTAN-2-ONE
CAS: 42924-53-8
MF: C15H16O2
MW: 228.29
EINECS:
Product Categories: Active Pharmaceutical Ingredients;Anti-Inflammatory;Analgesic;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Aromatics;API;BUTYN
Mol File: 42924-53-8.mol
Nabumetone Chemical Properties
Melting point 80-810C
Boiling point 330.1°C (rough estimate)
density 1.0657 (rough estimate)
refractive index 1.5542 (estimate)
storage temp. Refrigerator
solubility Soluble in alcohol or chloroform
form neat
Water Solubility 6mg/L(22.5 ºC)
CAS DataBase Reference 42924-53-8(CAS DataBase Reference)
NIST Chemistry Reference Nabumetone(42924-53-8)
Safety Information
Hazard Codes Xn
Risk Statements 22-40
Safety Statements 36/37
WGK Germany 2
RTECS EL9085000
HS Code 2914500000
Nabumetone Usage And Synthesis
Description Nabumetone is a non-acidic, nonsteroidal antiinflammatory agent formally related to naproxen. Its main circulating metabolite is 6-methoxy-2-naphthylacetic acid (α-nornaproxen). Administered once daily (Tsub>1/2 * 30 hrs), nabumetone is reported to be effective in the treatment of rheumatoid and osteoarthritis.
Chemical Properties White Powder
Originator Beecham (United Kingdom)
Uses Anti-inflamatory. Antibacterial
Uses Anti-inflammatory. Antibacterial.
Uses anesthetic (local)
Definition ChEBI: A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is s own to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
Indications Nabumetone (Relafen) is approved for rheumatoid arthritis, osteoarthritis, and pain management. Its long half-life allows for once-daily dosing. Although this drug is a weak inhibitor of COX, it is metabolized in the liver to 6-methoxy-2-naphthylacetic acid (6-MNA), a strong COX inhibitor that is chemically similar to naproxen. As with most NSAIDs, GI side effects are most commonly reported. The incidence of gastric ulceration is lower with nabumetone than with many other NSAIDs.This is due to its nature as a prodrug, not to COX-2 selectivity. Lower-bowel complaints, rashes, and CNS disturbances are common adverse effects.
Details
Product Name: Nabumetone
Synonyms: 4-[6-(trideuteriomethoxy)-2-naphthalenyl]-2-butanone;NABUMETONE, EP STANDARD;NABUMETONE, MM(CRM STANDARD);NABUMETONE, IMP. F (EP): 6,6'-DIMETHOXY-2,2'-BINAPHTHALENYL MM(CRM STANDARD);NABUMETONE, IMPURITY D(E)-4-(6-METHOXYNAPHTHALEN-2-YL)BUT-3-EN-2-ONE EP STANDARD;NABUMETONE, USP(CRM STANDARD);NABUMETONE, BP STANDARD;NABUMETONE:4-(6-METHOXY-2-NAPHTYLBUTAN-2-ONE
CAS: 42924-53-8
MF: C15H16O2
MW: 228.29
EINECS:
Product Categories: Active Pharmaceutical Ingredients;Anti-Inflammatory;Analgesic;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Aromatics;API;BUTYN
Mol File: 42924-53-8.mol
Nabumetone Chemical Properties
Melting point 80-810C
Boiling point 330.1°C (rough estimate)
density 1.0657 (rough estimate)
refractive index 1.5542 (estimate)
storage temp. Refrigerator
solubility Soluble in alcohol or chloroform
form neat
Water Solubility 6mg/L(22.5 ºC)
CAS DataBase Reference 42924-53-8(CAS DataBase Reference)
NIST Chemistry Reference Nabumetone(42924-53-8)
Safety Information
Hazard Codes Xn
Risk Statements 22-40
Safety Statements 36/37
WGK Germany 2
RTECS EL9085000
HS Code 2914500000
Nabumetone Usage And Synthesis
Description Nabumetone is a non-acidic, nonsteroidal antiinflammatory agent formally related to naproxen. Its main circulating metabolite is 6-methoxy-2-naphthylacetic acid (α-nornaproxen). Administered once daily (Tsub>1/2 * 30 hrs), nabumetone is reported to be effective in the treatment of rheumatoid and osteoarthritis.
Chemical Properties White Powder
Originator Beecham (United Kingdom)
Uses Anti-inflamatory. Antibacterial
Uses Anti-inflammatory. Antibacterial.
Uses anesthetic (local)
Definition ChEBI: A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is s own to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
Indications Nabumetone (Relafen) is approved for rheumatoid arthritis, osteoarthritis, and pain management. Its long half-life allows for once-daily dosing. Although this drug is a weak inhibitor of COX, it is metabolized in the liver to 6-methoxy-2-naphthylacetic acid (6-MNA), a strong COX inhibitor that is chemically similar to naproxen. As with most NSAIDs, GI side effects are most commonly reported. The incidence of gastric ulceration is lower with nabumetone than with many other NSAIDs.This is due to its nature as a prodrug, not to COX-2 selectivity. Lower-bowel complaints, rashes, and CNS disturbances are common adverse effects.