Cyproheptadine hydrochloride

Synonyms: CYPROHEPTADINE HCL; CYPROHEPTADINE HYDROCHLORIDE; CYPROHEPTADINE HYDROCHLORIDE HYDRATE; CYPROHEPTADINE HYDROCHLORIDE SESQUIHYDRATE; 4- (5H-DIBENZO [A, D] CYCLOHEPTEN-5-YLIDINE) -METHYLPIPERIDINE HYDROCHLORIDE; CYPROHEPTADINE HCL USP (CRM STANDARD); CYPROHEPTADINE HYDROCHLORIDE EPC ( CRM STANDARD); CyproheptadineHclUspGrade

CAS number: 41354-29-4

Molecular formula: C21H22ClN

Molecular weight: 323.86

EINECS No. 213-535-1

Related Categories: Building Blocks; Heterocyclic Building Blocks; Piperidines; Antiinflammatory and Analgesic Drugs; Antipyretic and Analgesic Drugs; Anti-allergic New Drugs; Heterocyclic Building Blocks; API; PERIACTIN; Antihistamines; General Reagents; Intermediates; pharmaceutical intermediates; raw materials; small molecule inhibitors; anti-viral anti-infectives; pharmaceutical raw materials; pyridine;

Mol file: 41354-29-4.mol

Cyproheptadine hydrochloride

Cyproheptadine Hydrochloride Nature

Melting point 165 ° C (dec.) (Lit.)

Solubility

Color white to slightly yellow

Maximum wavelength (λmax) 285 nm (0.05 mol / L H2SO4) (lit.)

Merck 14,2773

CAS Database 41354-29-4 (CAS DataBase Reference)

Hydrochloric acid cyproheptadine use and synthesis method

Antihistamines cyproteride hydrochloride, also known as diphenhydramine, nifedipine, ethyl benzene cycloheptane, antipyrine, is a piperidine antihistamines, with the release of the organization of the group Amine competes for H1 receptors on effector cells, thereby preventing the onset of anaphylactic reactions, releasing the spasm and hyperemia effects of histamine. This product has a strong H1 receptor antagonism, antihistamine effect than chlorpheniramine, Strong neck A mild, moderate anti-serotonin effects and anticholinergic effects. In addition, there is still the role of stimulating appetite, after taking a certain time visible weight gain.

Clinician cyproheptadine is mainly used for acute and chronic urticaria (especially cold urticaria have good effect), papular urticaria, angioedema, atopic eczema, contact dermatitis, food allergy, drug allergy, Allergic rhinitis, hay fever, allergic conjunctivitis, allergic insect bites and migraine. Bronchial asthma have a therapeutic effect. Can be used for Cushing syndrome, acromegaly adjuvant therapy. It is also used as an appetite enhancer for neuropathic fecal food. There are still reports of treatment of acanthosis nigricans disease, prevention of necrotic pyoderma.

Dosage Oral constant release dosage forms: (1) allergic diseases: adults, a 2 ~ 4mg, 2 to 3 times a day. (2) Cushing's syndrome, suitable for the treatment of bilateral adrenal hyperplasia cases, can inhibit hypothalamic release of corticotropin-releasing hormone (CRH) and inhibition of pituitary adrenocorticotropic hormone (ACTH) secretion, thereby reducing plasma ACTH and Cortisol levels; adult start the day 8mg, can be gradually increased to 24mg a day; commonly used dose of 12 ~ 24mg a day, taking several times, long-term application; bilateral adrenalectomy or subtotal cortical insufficiency Under the one hand, corticosteroids, on the one hand taking cyproheptadine can reduce the chance of pituitary tumor.

The above information is compiled by Andy, ChemicalBook's editor.

Uses for the treatment of urticaria, itchy skin, allergic rhinitis.

Use anticoagulant, anti-allergy drugs. Can be used for urticaria, eczema, allergic and contact dermatitis, skin itching and other allergic reactions. Urticaria, eczema, allergic and contact dermatitis, pruritus, rhinitis, migraine, bronchial asthma and the like. Can also be used for Cushing's disease and acromegaly.

Use 5-HT2 / 5-HT1C serotonin receptor antagonist; H1 histamine receptor antagonist; antipruritic agent