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tianfu-chem_Betamethasone，378-44-9 CAS NO.378-44-9
- Min.Order: 1 Kilogram
- Payment Terms: T/T,
- Product Details
Keywords
- 378-44-9
- Betamethasone
- 378-44-9
Quick Details
- ProName: tianfu-chem_Betamethasone，378-44-9
- CasNo: 378-44-9
- Molecular Formula: C11H20N2O2
- Appearance: Powder
- Application: For Pharmaceutical chenmical synthesis
- DeliveryTime: Prompt
- PackAge: In 25KG PP Drums
- Port: Shanghai
- ProductionCapacity: 10 Metric Ton/Month
- Purity: 99.0% Min
- Storage: In Room Temperature
- Transportation: Shipment by sea or Air as non-dangerou...
- LimitNum: 1 Kilogram
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Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:
1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
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Details
Product Name: Betamethasone
Synonyms: 17,21-trihydr;betamethasone standard;(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;Betamethasone Base & Salts;Betamethasone,9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16β-methylprednisolone;Betamethasone (200 mg);BetaMethasone (Celestone);BetaMethasone SolutioM
CAS: 378-44-9
MF: C22H29FO5
MW: 392.46
EINECS: 206-825-4
Product Categories: Steroid and Hormone;Pharmaceutical intermediate;CELESTONE;Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 378-44-9.mol
Betamethasone Structure
Betamethasone Chemical Properties
Melting point 235-237°C
alpha D +108° (acetone)
density 1.1283 (estimate)
refractive index 118 ° (C=1, Dioxane)
storage temp. 0-6°C
Merck 14,1180
CAS DataBase Reference 378-44-9(CAS DataBase Reference)
NIST Chemistry Reference Pregna-1,4-diene-3,20-dione, 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-(378-44-9)
Safety Information
Hazard Codes Xi,Xn,T
Risk Statements 40-48/20/21-61
Safety Statements 22-36-45-53
RTECS TU4000000
HS Code 29379000
Hazardous Substances Data 378-44-9(Hazardous Substances Data)
MSDS Information
Betamethasone Usage And Synthesis
hormone drugs Betamethasone, belongs to adrenal corticosteroids, it is a isomer of dexamethasone , and the role of betamethasone is similiar to prednisolone and dexamethasone , it has anti-inflammatory, anti-rheumatic, anti-allergic and suppression of the immune and other pharmacological effects, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone etc. , it can reduce and prevent tissue response to inflammation and eliminate heat, redness and swelling caused by local non-infectious inflammation, thereby reducing the performance of inflammation, anti-inflammatory effect of this product 0.3mg is equal to dexamethasone 0.75mg, prednisone 5mg or 25mg cortisone .
Betamethasone sodium retention effect is a hundred times more than hydrocortisone, in primary adrenal hypofunction, it can be used together with glucocorticoid for replacement therapy ,and it is used for preventing or inhibiting cell-mediated immune response, delaying allergic reactions and reducing the primary immune response expansion ,it is used for low renin and low aldosterone syndrome and autonomic neuropathy induced orthostatic hypotension.
Currently betamethasone is also used for the treatment of active rheumatoid arthritis, rheumatoid arthritis, lupus, severe bronchial asthma, severe dermatitis, acute leukemia, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, and pruritus and comprehensive treatment of certain infections.
The product is contraindicated in severe psychiatric history, active duodenal ulcer, recent gastrointestinal anastomosis, heavier osteoporosis, overt diabetes, severe hypertension, virus , bacterial, fungal infections which are failed to control by the use of antimicrobial agents , thrombophlebitis, skin infections, such as impetigo, tinea, jock itch and so on.
The above information is edited by the chemicalbook of Tian Ye.
Chemical Properties White crystalline powder. Mp 231-234 deg.] C (decomposition). Odorless. Acetate Betamethasone ([987-24-6]) is also white crystalline powder, melting point 205-208 ℃, slightly soluble in alcohol, ethanol, and very slightly soluble in chloroform or ether, insoluble in water, odorless.
Uses Hormone drugs.It is mainly used for anti-inflammatory and anti-allergic. It is suitable for rheumatoid arthritis and various skin diseases. Betamethasone role is similiar to dexamethasone, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone and it has few side effects.
production method According to U.S. Patent No. 3,164,618, betamethasone acetate is dealt with hydrochloric acid in methanol-chloroform-water mixture , it can be converted to betamethasone.
Category Toxic substances
Toxicity grading Middle toxic
Acute toxicity Oral-mouse LD50:> 4500 mg/kg
Flammability and hazard characteristics Combustible;Its combustion produces toxic fumes of fluoride.
Storage Characteristics Ventilated, low-temperature ,dry storeroom.
Extinguishing agent Dry powder , foam, sand, carbon dioxide, water spray.
Chemical Properties White to Off-White Solid
Uses glucocorticoid, antiinflammatory
Uses Betamethasone is a glucocorticoid used as an anti-inflammatory agent.
Uses anti-inflammatory, immunosuppressive
Brand name Celestone Syrup and Tablets (Schering).
Purification Methods Betamethasone crystallises from ethyl acetate, and has max at 238nm (log 4.18) in MeOH. The 21-acetate [287-24-6] crystallises from Me2CO/Et2O (charcoal) m 196-201o (205-208o) and has [] D 20 +140o (CHCl3). [Taub et al. J Am Chem Soc 82 4012 1960, Olivetto et al. J Am Chem Soc 80 6688 1958, Beilstein 8 IV 3501.]