Product Name: Heptafluorobutyric acid
Synonyms: 2,2,3,3,4,4,4-heptafluorobutanoate;uorobutyric acid;Heptafluorobutyric Acid (ca. 0.5mol/L in Water) [Ion-Pair Reagent for LC-MS];PERFLUOROBUTYRATE;Heptafluorobutyricacid99%;Heptafluorobutyric acid, for protein sequence analysis, 99%;HAPTAFLUORO-N-BUTYRIC ACID;HEPTAFLUOROBUTYRIC ACID, FOR PROTEIN SEQ UENTIAL ANALYSIS
CAS: 375-22-4
MF: C4HF7O2
MW: 214.04
EINECS: 206-786-3
Product Categories: GC Derivatizing Reagents;HPLC and LCMS Mobile Phase Additive;Pharmaceutical Intermediates;Analytical Chemistry;Ion-Pair Reagents for HPLC;LC/MS Ion-Pair Reagents for Basic Samples;Acylation (GC Derivatizing Reagents)
Mol File: 375-22-4.mol

Heptafluorobutyric acid Chemical Properties
Melting point  -17.5 °C
Boiling point  120 °C755 mm Hg(lit.)
density  1.645 g/mL at 25 °C(lit.)
vapor density  7 (vs air)
vapor pressure  ~10 mm Hg ( 25 °C)
refractive index  n20/D 1.3(lit.)
Fp  120-121°C
storage temp.  2-8°C
pka pK1:0.17 (25°C)
form  Powder
color  Clear colorless to faint yellow
Specific Gravity approximate 1.6
PH 1 (H2O, 20℃)
Water Solubility  miscible
Sensitive  Light Sensitive
BRN  1426882
InChIKey YPJUNDFVDDCYIH-UHFFFAOYSA-N
CAS DataBase Reference 375-22-4(CAS DataBase Reference)
NIST Chemistry Reference Butanoic acid, heptafluoro-(375-22-4)
EPA Substance Registry System Heptafluorobutyric acid (375-22-4)
Safety Information
Hazard Codes  C
Risk Statements  34-35
Safety Statements  26-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  3
RTECS  ET4025000
F  3-8-10
Hazard Note  Corrosive
TSCA  T
HazardClass  8
PackingGroup  II
HS Code  29159000

Heptafluorobutyric acid Usage And Synthesis
Chemical Properties Clear colorless to faintly yellow liquid
Uses Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.

Product Name: Heptafluorobutyric acid
Synonyms: 2,2,3,3,4,4,4-heptafluorobutanoate;uorobutyric acid;Heptafluorobutyric Acid (ca. 0.5mol/L in Water) [Ion-Pair Reagent for LC-MS];PERFLUOROBUTYRATE;Heptafluorobutyricacid99%;Heptafluorobutyric acid, for protein sequence analysis, 99%;HAPTAFLUORO-N-BUTYRIC ACID;HEPTAFLUOROBUTYRIC ACID, FOR PROTEIN SEQ UENTIAL ANALYSIS
CAS: 375-22-4
MF: C4HF7O2
MW: 214.04
EINECS: 206-786-3
Product Categories: GC Derivatizing Reagents;HPLC and LCMS Mobile Phase Additive;Pharmaceutical Intermediates;Analytical Chemistry;Ion-Pair Reagents for HPLC;LC/MS Ion-Pair Reagents for Basic Samples;Acylation (GC Derivatizing Reagents)
Mol File: 375-22-4.mol

Heptafluorobutyric acid Chemical Properties
Melting point  -17.5 °C
Boiling point  120 °C755 mm Hg(lit.)
density  1.645 g/mL at 25 °C(lit.)
vapor density  7 (vs air)
vapor pressure  ~10 mm Hg ( 25 °C)
refractive index  n20/D 1.3(lit.)
Fp  120-121°C
storage temp.  2-8°C
pka pK1:0.17 (25°C)
form  Powder
color  Clear colorless to faint yellow
Specific Gravity approximate 1.6
PH 1 (H2O, 20℃)
Water Solubility  miscible
Sensitive  Light Sensitive
BRN  1426882
InChIKey YPJUNDFVDDCYIH-UHFFFAOYSA-N
CAS DataBase Reference 375-22-4(CAS DataBase Reference)
NIST Chemistry Reference Butanoic acid, heptafluoro-(375-22-4)
EPA Substance Registry System Heptafluorobutyric acid (375-22-4)
Safety Information
Hazard Codes  C
Risk Statements  34-35
Safety Statements  26-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  3
RTECS  ET4025000
F  3-8-10
Hazard Note  Corrosive
TSCA  T
HazardClass  8
PackingGroup  II
HS Code  29159000

Heptafluorobutyric acid Usage And Synthesis
Chemical Properties Clear colorless to faintly yellow liquid
Uses Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.