- Product Details
Keywords
- Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)-
- 98.0%
- 362-07-2
Quick Details
- ProName: 362-07-2 2-METHOXYESTRADIOL
- CasNo: 362-07-2
- Molecular Formula: C19H26O3
- Appearance: Solid
- Application: Organic Chemicals
- DeliveryTime: 7days
- PackAge: as clients needs
- Port: Qingdao
- ProductionCapacity: 1 Metric Ton/Day
- Purity: 99%
- Storage: In Room Temperature
- Transportation: by courier by sea
- LimitNum: 1 Gram
Superiority
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:
1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
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1. Higest quality and good package
2.Fast delivery
3.Better payment term
4.Fast response to customer within 6 hours
5.Good business credit in Europe ,US ,Japan ,Korea
Anyway ,if you need any chemicals from China ,Henan Tianfu can help you
Details
2-METHOXYESTRADIOL Basic information
Product Name: 2-METHOXYESTRADIOL
Synonyms: 2,3,17BETA-TRIHYDROXY-1,3,5[10]-ESTRATRIENE 2-METHYL ETHER;3,17BETA-DIHYDROXY-2-METHOXY-1,3,5[10]-ESTRATRIENE;2-METHOXY-3,17BETA-DIHYDROXYESTRA-1,3,5(10)-TRIENE;2-METHOXY-ESTRA-1,3,5(10)-TRIENE-3,17BETA-DIOL;2-METHOXYESTRADIOL;1,3,5(10)-ESTRATRIENE-2,3,17BETA-TRIOL 2-METHYL ETHER;1,3,5[10]-ESTRATRIENE-2,3,17-TRIOL 2-METHYL ETHER;1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER
CAS: 362-07-2
MF: C19H26O3
MW: 302.41
EINECS:
Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids;Inhibitor;2-ME2;Isolabel;Inhibitors
Mol File: 362-07-2.mol
2-METHOXYESTRADIOL Structure
2-METHOXYESTRADIOL Chemical Properties
Melting point 188-190°C
storage temp. −20°C
solubility DMSO: 10 mg/mL
form crystalline
color light yellow
CAS DataBase Reference 362-07-2(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xi,N
Risk Statements 23/24/25-36/37/38-48-61-60-46-45-51/53
Safety Statements 22-26-36/37/39-45-53-36-61
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS KG7537500
MSDS Information
Provider Language
SigmaAldrich English
2-METHOXYESTRADIOL Usage And Synthesis
Chemical Properties Off-White Solid
Usage A natural metabolite of 17Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a
Usage A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly
Usage 2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.
Usage 2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.
Usage 2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
Biological Activity Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.