Product Name: Retinoic acid
Synonyms: Tretinoin Retinoic acid in stock Factory;Isotretinoin Impurity 1（Isotretinoin EP Impurity A）;TRETINOIN;TRETINOIN VITAMIN A ACID;TRANS-RETINOIC ACID;TRANS VITAMIN A ACID;VITAMIN A ACID;VITAMIN A ACID, ALL-TRANS
CAS: 302-79-4
MF: C20H28O2
MW: 300.44
EINECS: 206-129-0
Product Categories: Intracellular receptor;API;intermediates;Inhibitors;PHARMACEUTICALS;Active Pharmaceutical Ingredients;APIs;Biochemistry;Terpenes;Terpenes (Others);Vitamins;Intermediates & Fine Chemicals;Retinoids
Mol File: 302-79-4.mol

Retinoic acid Chemical Properties
Melting point  180-181 °C(lit.)
Boiling point  381.66°C (rough estimate)
density  1.0597 (rough estimate)
refractive index  1.4800 (estimate)
storage temp.  2-8°C
solubility  Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
pka 4.73±0.33(Predicted)
form  powder
color  yellow
Water Solubility  insoluble
Sensitive  Light Sensitive
Merck  14,8165
BRN  2057223
Stability: Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months.
InChIKey SHGAZHPCJJPHSC-ZVCIMWCZSA-N
CAS DataBase Reference 302-79-4(CAS DataBase Reference)
EPA Substance Registry System Retinoic acid (302-79-4)

Safety Information
Hazard Codes  T,Xn,N
Risk Statements  22-63-38-20/21/22-51/53
Safety Statements  53-26-36/37/39-45-36/37-61-24/25
RIDADR  3249
WGK Germany  3
RTECS  VH6475000
F  7-8-16-23
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29362100
Hazardous Substances Data 302-79-4(Hazardous Substances Data)
Toxicity LD50 (10 day) in mice, rats (mg/kg): 790, 790 i.p.; 2200, 2000 orally (Kamm)

Retinoic acid Usage And Synthesis
Dermatology drugs Retinoic acid（Tretinoin） is commonly used in dermatology drugs, which is the department of vitamin A (Victoria methanol) metabolic intermediates.It mainly affects the growth of bones and epithelial metabolism, can promote epithelial cell proliferation and updates, and can inhibit the proliferation and differentiation of keratinocytes, so hyperkeratosis can be back to normal. Therefore many complete or incomplete keratosis, hyperkeratosis of diseases have a certain therapeutic effect, treat a variety of skin diseases. The use of the drug can penetrate topical skin quickly, enable significantly increased epithelial cell turnover. This class of drugs has strong and rapid inhibition on the secretion of the sebaceous glands, can reduce sebum secretion. In addition, the product also has anti-tumor, promote wound healing and anti-inflammatory effects.
Clinical application Retinoic acid is mainly used in the treatment of psoriasis, ichthyosis, follicular keratosis, acne, lichen planus, verrucous epidermal nevus, impetigo, vitiligo, lichen psoriasis, the face of pityriasis alba, etc. In addition, the drugs also have some preventive effect on skin cancer.

Physicochemical property Retinoic acid is a yellow needle crystal, with a similar smell of vitamin acetate. Soluble in methanol, ethanol,  dichloromethane , also in vegetable oil and fatty. In case of light, it is thermal instability, suck up moisture in the air, polymerization and metamorphism in water. The melting point of all trans-vitamin A acid is 182~180°C, the melting range of which is mixed with a small amount of isomers is 170~190°C.