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Atenolol Basic information
Pharmacological Affects Chemical Property Uses
Product Name: Atenolol
Synonyms: [(2S)-3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxypropyl]-propan-2-ylammonium;atenolol,tenormine;ATENOLOL, USP;AtenololAtenololBp/Usp;ATENOLOL, PHARMA;4-[2-Hydroxy-3-[(1-methyl-ethyl)amino]propoxyl]benzeneacetamide;Cuxanorm;Unilo
CAS: 29122-68-7
MF: C14H22N2O3
MW: 266.34
EINECS: 249-451-7
Product Categories: Pharmaceutical;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Adrenoceptor;Amines;Aromatics;API;Isotope;TENORMIN;Other APIs
Mol File: 29122-68-7.mol
Atenolol Structure
Atenolol Chemical Properties
Melting point  154°C
Boiling point  409.54°C (rough estimate)
density  1.0807 (rough estimate)
refractive index  1.5110 (estimate)
Fp  2℃
storage temp.  Store at RT
solubility  H2O: 0.3 mg/mL
pka 9.6(at 25℃)
form  powder
color  white to off-white
Water Solubility  13.5mg/L(25 ºC)
Merck  14,859
InChIKey METKIMKYRPQLGS-UHFFFAOYSA-N
CAS DataBase Reference 29122-68-7(CAS DataBase Reference)
NIST Chemistry Reference Atenolol(29122-68-7)
EPA Substance Registry System Benzeneacetamide, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]- (29122-68-7)
Safety Information
Hazard Codes  Xn,F
Risk Statements  22-36/37/38-20/21/22-36-11
Safety Statements  22-24/25-36-26-36/37-16
RIDADR  UN 1648 3 / PGII
WGK Germany  2
RTECS  AC3600000
HazardClass  IRRITANT
HS Code  29242995
Hazardous Substances Data 29122-68-7(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): 2000, 3000 orally; 98.7, 59.24 i.v. (Fitzgerald)
MSDS Information
Provider Language

Atenolol Usage And Synthesis
Pharmacological Affects Atenolol ,also known as atenolol, Aten Yue Er, tamoxifen, downhill Ling blood pressure, Tenormin, blood pressure Ling, is a long-acting cardioselective β1-adrenergic blockers, without intrinsic sympathomimetic activity or membrane stability.The atenolol,s retardation for β1 adrenaline receptors is similar with metoprolol, propranolol and nadolol , which is 1/6 times for pindolol and timolol. But, it does not inhibit the effect of the isoproterenol bronchodilator.When administered in small doses, it does not like non-selective β-adrenergic blockers as aggravated hypoglycemia induced hypertensive crisis, peripheral circulatory impairment or patients with obstructive airways disease worsening airway function and so on. However, When administered in large doses, atenolol also can decrease asthma or chronic obstructive pulmonary disease, airway function. Atenolol, as a long-term treatment of hypertension, also were reported for affecting airway function. Thus, despite atenolol heart selection, chronic obstructive pulmonary disease patients can only use small doses, but also should be given a sufficient amount of β1-adrenergic receptor agonists.
Oral F is 46%~60%, Tmax about 2~4 h, Mainly unchanged since the urine excretion, T1/2 of 6~7 h. Hemodialysis can clear the goods. Rapidly absorbed from the gastrointestinal tract, but not exclusively.The rest of the body is excreted in the stool. Food can reduce the F, fasting and after meals AUC decreased by 20%. Distribution of the central nervous system is relatively few. The ratio of brain tissue to blood concentration was 0.1:1. Easy to achieve in the placenta and the maternal plasma concentrations of same. PPB is less than 5%, Vd is 50~75 L. Atenolol is not metabolized by the liver, most of the drug is excreted from the body in urine, renal insufficiency in patients with T1/2 was significantly prolonged. Patients with renal failure range of T1/2 was 10~28 h, or even up to 100 h. Results at 24 h after, the discharge from the urine of the drug can be reduced by 29%. The T1/2 of patients with hyperthyroidism was significantly shortened, 4.2h.
The above information is edited by the chemicalbook of Kui Ming.
Chemical Property White powder. Melting point (146-148 ℃). Soluble in alcohol, slightly soluble in water, chloroform, Hardly soluble in ethyl ether, slightly smelly.
Uses β-blockers. Clinical application in the treatment of hypertension, angina and arrhythmia.
Chemical Properties White or almost white powder.
Uses Selective b1 adrenergic receptor agonist, anti-hypertensive, anti-anginal, anti-arrhythmic
Definition ChEBI: An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.
Brand name Tenormin (AstraZeneca).
Biological Activity Cardioselective β -adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.
Veterinary Drugs and Treatments Atenolol may be useful in the treatment of supraventricular tachyarrhythmias, premature ventricular contractions (PVC’s, VPC’s), systemic hypertension and in treating cats with hypertrophic cardiomyopathy. Atenolol is relatively safe to use in animals with bronchospastic disease.
Metabolism Roughly half of an orally administered dose of atenolol (Tenormin) is absorbed.The drug is eliminated primarily by the kidney and unlike propranolol, undergoes little hepatic metabolism. Its plasma half-life is approximately 6 hours, although if it is administered to a patient with impaired renal function, its half-life can be considerably prolonged.
Atenolol Preparation Products And Raw materials
Raw materials 4'-Hydroxyacetophenone