Product Name: Dexrazoxane
Synonyms: (S)-ICRF-187;[S,(+)]-4,4'-Propylenebis(2,6-piperazinedione);4,4'-[(S)-1-Methyl-1,2-ethanediyl]bis(2,6-piperazinedione);4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dionehydrochloride;4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;(S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione);Dexrazoxane ((S)-Razoxane);2,6-Piperazinedione,4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-
CAS: 24584-09-6
MF: C11H16N4O4
MW: 268.27
EINECS:
Product Categories: API;Chelating Agent
Mol File: 24584-09-6.mol

Dexrazoxane Chemical Properties
Melting point  194-196°C
alpha  D +11.35° (c = 5 in DMF)
Boiling point  531.5±50.0 °C(Predicted)
density  1.333±0.06 g/cm3(Predicted)
storage temp.  Desiccate at RT
solubility  DMSO: >20mg/mL
form  powder
pka 2.1(at 25℃)
color  white to off-white
Merck  14,8123
InChIKey BMKDZUISNHGIBY-ZETCQYMHSA-N
CAS DataBase Reference 24584-09-6(CAS DataBase Reference)
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
RTECS  TL6390000
Hazardous Substances Data 24584-09-6(Hazardous Substances Data)

Dexrazoxane Usage And Synthesis
Description Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.
Originator Imperial Cancer Research Fund (United Kingdom)
Uses Cardioprotectant.
Brand name Zinecard (Pharmacia & Upjohn);Cardioxane.
Biological Activity Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Product Name: Dexrazoxane
Synonyms: (S)-ICRF-187;[S,(+)]-4,4'-Propylenebis(2,6-piperazinedione);4,4'-[(S)-1-Methyl-1,2-ethanediyl]bis(2,6-piperazinedione);4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dionehydrochloride;4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;(S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione);Dexrazoxane ((S)-Razoxane);2,6-Piperazinedione,4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-
CAS: 24584-09-6
MF: C11H16N4O4
MW: 268.27
EINECS:
Product Categories: API;Chelating Agent
Mol File: 24584-09-6.mol

Dexrazoxane Chemical Properties
Melting point  194-196°C
alpha  D +11.35° (c = 5 in DMF)
Boiling point  531.5±50.0 °C(Predicted)
density  1.333±0.06 g/cm3(Predicted)
storage temp.  Desiccate at RT
solubility  DMSO: >20mg/mL
form  powder
pka 2.1(at 25℃)
color  white to off-white
Merck  14,8123
InChIKey BMKDZUISNHGIBY-ZETCQYMHSA-N
CAS DataBase Reference 24584-09-6(CAS DataBase Reference)
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
RTECS  TL6390000
Hazardous Substances Data 24584-09-6(Hazardous Substances Data)

Dexrazoxane Usage And Synthesis
Description Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.
Originator Imperial Cancer Research Fund (United Kingdom)
Uses Cardioprotectant.
Brand name Zinecard (Pharmacia & Upjohn);Cardioxane.
Biological Activity Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.