TIANFU-CHEM - Ipratropium bromide CAS NO.22254-24-6

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Product Details

Keywords

Ipratropium bromide
?22254-24-6
C20H30BrNO3

Quick Details

ProName: TIANFU-CHEM - Ipratropium bromide
CasNo: 22254-24-6
Molecular Formula: C20H30BrNO3
Appearance: Solid
Application: Organic synthesis
DeliveryTime: PROMPT
PackAge: IN 25kg drums
Port: SHANGHAI
ProductionCapacity: 10 Metric Ton/Month
Purity: 99.0%
Storage: In Room Temperature
Transportation: As per MSDS
LimitNum: 1 Gram
Heavy metal: N/A
Grade: Industrial Grade,Food Grade,Pharma Gra...

Superiority

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license.

We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the company is to put quality first and put our customer’s needs first - the satisfaction of our customers is the company's ultimate goal.

Improving product quality and service level is our responsibility, and creating more value for our customer’s is our purpose. We are constantly striving to make Henan Tianfu a leading chemical supplier, and hope to create a better future with you.

Details

Ipratropium bromide Basic information

Pharmacology and toxicology Indication Precaution Drug overdose Adverse reaction

Product Name: Ipratropium bromide

Synonyms: 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, (endo,syn)-, bromide;8-Isopropylatropinium bromide;3-alpha-Hydroxy-8-isopropyl-1-alpha-H,5-alpha-H-tropanium bromide (±)-tropate;2-Methyl-2-[(piperidinomethyl)thio]propionic acid;Ipratropium bromide;Ipratropium Bromide anhydrous;(endo,syn)-(±)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octanebromide;Ipratropium bromide monohydrate,Atropine isopropyl bromide

CAS: 22254-24-6

MF: C20H30BrNO3

MW: 412.37

EINECS: 244-873-8

Product Categories: Acetylcholine receptor;Inhibitors;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals

Mol File: 22254-24-6.mol

Ipratropium bromide Structure

Ipratropium bromide Chemical Properties

Melting point 230-232°C

RTECS YM3700000

storage temp. Store at RT

solubility H2O: 10 mg/mL

form powder

color white

Water Solubility Freely soluble

Stability: Stable. Incompatible with strong oxidizing agents.

CAS DataBase Reference 22254-24-6(CAS DataBase Reference)

Safety Information

Hazard Codes Xn

Risk Statements 20/22-36

Safety Statements 26

WGK Germany 3

MSDS Information

Provider Language

Ipratropium bromide English

SigmaAldrich English

Ipratropium bromide Usage And Synthesis

Pharmacology and toxicology Ipratropium bromide is also known as isoprenaline, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropium bromide, isopropyl atropine, isopropyl atropine bromide, ipratropium bromide, bromo ipratropium bromide. It is a white crystalline powder with bitter taste and melting point of 232℃-233℃. It is soluble in water, slightly soluble in ethanol and insoluble in other organic solvents. Chemical name is Brominated alpha (methylol) - phenylacetic acid -8- methyl -8- isopropyl- azacyclo [3, 2, 1]-3- octyl. It is an anticholinergic drug and can relax the bronchial smooth muscle.It has an antiasthmatic effect on chronic obstructive pulmonary disease.The effect is obvious, fast and enduring. Isopatropium also has the effect of controlling the secretion of the mucous glands and improving the ciliated movement, thereby reducing the obstruction of sputum to improve ventilation. At the same time, the decrease of sputum also relieves bronchospasm caused by bronchial irritation.It is used for the prevention and treatment of bronchial asthma and asthma type chronic bronchitis. Especially it is applicable to patients with a beta agonist that produces muscle tremor, tachycardia and can not tolerate such kind of drugs. The combination of this product and beta agonist can enhance the efficacy of each other.For example, it can be combined with fenoterol into aerosol (BERODU - AL) for treating asthma, chronic bronchitis and emphysema.Compared with beta adrenergic receptor stimulants (such as isopropylepinephrine), this product has less side effects on the cardiovascular system.

Compared with the beta 2- receptor stimulant (such as broncovaleas ), this product has a strong regulating effect on the amount of phlegm.

Indication For the prevention and treatment of bronchial asthma and asthma type chronic bronchitis. Especially it is applicable to the patients with a beta agonist that produces muscle tremor, tachycardia and can not tolerate such drugs. The combination of this product and beta agonist can enhance the efficacy of each other. For example, it can be combined with fenoterol into aerosol (BERODU - AL) for treating asthma, chronic bronchitis and emphysema.

Precaution

Prohibition It is prohibited for people who are allergic to soy lecithin or related foods such as soya and peanuts and those who are allergic to atropine or its derivatives or other ingredients of this product. It is also prohibited for the patients with hypertrophic obstructive cardiomyopathy, fast arrhythmia and pyloric obstruction.

Cautious use It should be used in caution for patients with a tendency to narrow angle glaucoma, a benign prostatic hyperplasia, or a bladder neck obstruction.

The use of beta adrenergic stimulants or xanthine agents can enhance the bronchiectasis of the drug.

The most common non respiratory adverse reactions are headache, nausea, dry mouth, dysphonia, vertigo, anxiety, tachycardia, skeletal muscle fine tremor and palpitation.

If the atomized ipratropium bromide is used alone or in combination with adrenaline beta 2- receptor agonist, when the atomizer enters the eye, it may have ocular complications, such as large pupil, increased intraocular pressure, angle closure glaucoma, and eye pain.

Drug overdose Cholinesterase inhibitor can be used in the treatment of severe anticholinergic drug poisoning.

Adverse reaction The adverse reaction of ipratropium bromide is similar to atropine, which can cause palpitation, headache, dizziness, nervousness, nausea and vomiting, alimentary tract pain, tremor, blurred vision, dry mouth and cough, dysuria, respiratory symptoms aggravating and rash.

Chemical Properties White Powder

Uses N-Isopropyl quaternary salt of Atropine. Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator

Definition ChEBI: The anhydrous form of the bromide salt of ipratropium. An anticholinergic drug, ipratropium bromide blocks the muscarinic cholinergic receptors in the smooth muscles of the bronchi in the lungs. This opens the bronchi, so providing relief in chronic obstru tive pulmonary disease and acute asthma.

Biological Activity Muscarinic antagonist, bronchodilator. N-Isopropyl salt of atropine.

Ipratropium bromide Preparation Products And Raw materials