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Diclofenac potassium Basic information
Description References
Product Name: Diclofenac potassium
Synonyms: DICLOFENAC POTASSIUM /POTASSIUM [2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL]ACETATE;Cataflam;CGP-45840B;K-fenak;Keflan;Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-, monopotassium salt;PotassiuM diclofenac;ProSorb
CAS: 15307-81-0
MF: C14H10Cl2KNO2
MW: 334.24
EINECS: 630-422-6
Product Categories: Active Pharmaceutical Ingredients;chiral;Inhibitors;API's
Mol File: 15307-81-0.mol
Diclofenac potassium Structure
Diclofenac potassium Chemical Properties
Melting point  300-330 °C
solubility  Sparingly soluble in water, freely soluble in methanol, soluble in ethanol (96 per cent), slightly soluble in acetone.
form  neat
CAS DataBase Reference 15307-81-0(CAS DataBase Reference)
Safety Information
Hazard Codes  Xn,N
Risk Statements  22-51/53
Safety Statements  61
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2922492050
MSDS Information
Diclofenac potassium Usage And Synthesis
Description Dichlofenac potassium is the potassium salt of dichlofenac. It is a nonsteroidal anti-inflammatory agent that can be used to reduce inflammation and as an analgesic to reduce pain in certain conditions. It can also used to treat dysmenorrhea. It can treat inflammatory disorders such as musculoskeletal complaints, dental pain, arthritis, actinic keratosis, joint pain, acute pain and chronic pain caused by certain kinds of cancers. Traditional opinion proposes that diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. However, recent studies have shown that the pharmacologic activity of diclofenac goes beyond COX inhibition, and includes multimodal and, in some instances, novel mechanisms of action (MOA). For example, research suggests diclofenac can inhibit the thromboxane-prostanoid receptor, affect arachidonic acid release and uptake, inhibit lipoxygenase enzymes, and activate the nitric oxide–cGMP antinociceptive pathway. Other novel MOAs may include the inhibition of substrate P, inhibition of peroxisome proliferator activated receptor gamma (PPARγ), blockage of acid-sensing ion channels, alteration of interleukin-6 production, and inhibition of N-methyl-D-aspartate (NMDA) receptor hyperalgesia.
References Brogden, R. N., et al. "Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin." Drugs 20.1 (1980): 24-48.
Gan, Tong J. "Diclofenac: an update on its mechanism of action and safety profile." Current medical research and opinion 26.7 (2010): 1715-1731.
Riihiluoma, P., E. Wuolijoki, and M. O. Pulkkinen. "Treatment of primary dysmenorrhea with diclofenac sodium." European Journal of Obstetrics & Gynecology and Reproductive Biology 12.3 (1981): 189-194.
Chemical Properties White or slightly yellowish, slightly hygroscopic, crystalline powder.
Uses Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.
Definition ChEBI: The potassium salt of diclofenac.
Brand name Cataflam (Novartis).
Diclofenac potassium Preparation Products And Raw materials