TIANFU-CHEM - Tropicamide CAS NO.1508-75-4

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Product Details

Keywords

Tropicamide
1508-75-4
C17H20N2O2

Quick Details

ProName: TIANFU-CHEM - Tropicamide
CasNo: 1508-75-4
Molecular Formula: C17H20N2O2
Appearance: Solid
Application: Organic synthesis
DeliveryTime: PROMPT
PackAge: IN 25kg drums
Port: SHANGHAI
ProductionCapacity: 10 Metric Ton/Month
Purity: 99.0%
Storage: In Room Temperature
Transportation: As per MSDS
LimitNum: 1 Gram
Heavy metal: N/A
Grade: Industrial Grade,Food Grade,Pharma Gra...

Superiority

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license.

We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the company is to put quality first and put our customer’s needs first - the satisfaction of our customers is the company's ultimate goal.

Improving product quality and service level is our responsibility, and creating more value for our customer’s is our purpose. We are constantly striving to make Henan Tianfu a leading chemical supplier, and hope to create a better future with you.

Details

Tropicamide Basic information

Ophthalmic drugs Uses

Product Name: Tropicamide

Synonyms: Tropicamide (200 mg);(2R)-N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylMethyl)propanaMide;TropicaMide N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylMethyl)propanaMide;Tropicamide for peak identification;Tropicamide WS;Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-;bistropamide;component of Paremyd

CAS: 1508-75-4

MF: C17H20N2O2

MW: 284.35

EINECS: 216-140-2

Product Categories: Inhibitors;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor

Mol File: 1508-75-4.mol

Tropicamide Structure

Tropicamide Chemical Properties

Melting point 98 °C

storage temp. 2-8°C

solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL

form solid

color white

λmax 254nm(HCl aq.)(lit.)

Merck 14,9780

CAS DataBase Reference 1508-75-4(CAS DataBase Reference)

NIST Chemistry Reference Tropicamide(1508-75-4)

Safety Information

Hazard Codes Xn,Xi

Risk Statements 20/21/22-36/37/38-42/43-41-37/38-22

Safety Statements 22-26-36-36/37/39

WGK Germany 3

RTECS CY1487860

MSDS Information

Provider Language

N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide English

SigmaAldrich English

Tropicamide Usage And Synthesis

Ophthalmic drugs Tropicamide is an anticholinergic agent. At room temperature, it is a white crystalline powder and is odorless. It is slightly soluble in water and easily soluble in ethanol, dilute hydrochloric acid, sulfuric acid and chloroform. It can block the excitement of iris sphincter and ciliary muscle induced by acetylcholine. Its 0.5% solution can cause mydriasis while its 1% solution can cause ciliary muscle paralysis and mydriasis. Clinically it is mainly used for the treatment of eye drops mydriasis and paralysis.

Tropicamide is the synthetic derivative of tropic acid. It has a relative low dissociation constant with good intraocular permeability and strong tissue diffusion capability which may be the underlying mechanism for its quick onset but short maintaining time. After the drop of the 0.5% or 1% solution of this product, the instillation dilation and paralysis adjustment can reach peak within 20-30 minutes. Then the effect gradually decreases with adjusting paralysis (residual) for 2 to 6 hours and mydriasis (residual) for about 7 hours. Tropicamide is similar drug as atropine which can cause a dramatic increase on the angle closure glaucoma intraocular pressure as well as possibly stimulate undiagnosed angle-closure glaucoma.

The potency of ciliary muscle paralysis adjustment of tropicamide eye drops is closely related with the doses used, its 0.25%, 0.5%, 0.75% and 1% four concentrations can all adjust paralysis. After instillation, the maximum degree of residual adjustment is 0.25%: diopter: 3.17; 1% diopter: 3.17. The residue adjustment degree can be maintained in cases of the refraction being 2.0 or less, 0.75% and 1% solutions can maintain for 40 minutes while 0.5% can only maintain about 15 minutes. After a drop of 1% solution, have the second drop after 5 to 25 minutes and by doing this, we can get more satisfactory ciliary muscle paralysis effect for about 20 to 30 minutes. After 2 to 6 hours, you can read books and newspapers with the adjustment function being able to recover to the level before drop within 6 hours.

The above information is edited by the Chemicalbook of Dai Xiongfeng.

Uses It can be used as an anti-cholinergic drugs or mydriatic drug.

It is a kind of M4 muscarinic acetylcholine receptor antagonist.

Chemical Properties Crystalline Solid

Uses antidepressant, nutrient; LD50(rat) 1634 mg/kg ip

Uses Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye.

Uses Ophthalmic anticholinergic. Mydriatic

Biological Activity M 4 selective muscarinic receptor antagonist.

Tropicamide Preparation Products And Raw materials