Product Name: 2-Thiouracil
Synonyms: 2-mercapto-4(1h)-pyrimidinone;2-mercapto-4-pyrimidino;2-Mercapto-4-pyrimidinol;2-Mercaptopyrimid-4-one;2-Sulfanyl-4-pyrimidinol;2-Thio-1,3-pyrimidin-4-one;2-thio-2,4-(1h,3h)-pyrimidinedione;2-thio-4-oxo-1,3-pyrimidine
CAS: 141-90-2
MF: C4H4N2OS
MW: 128.15
EINECS: 205-508-8
Product Categories: PYRIMIDINE;FINE Chemical & INTERMEDIATES;Pyridines, Pyrimidines, Purines and Pteredines;Heterocyclic Compounds;Nucleic acids;Bases & Related Reagents;Nucleotides;Sulfur & Selenium Compounds;Building Blocks;C4 to C5;Chemical Synthesis;Heterocyclic Building Blocks;Pyrimidines
Mol File: 141-90-2.mol

2-Thiouracil Chemical Properties
Melting point  >300 °C(lit.)
density  1.368 (estimate)
refractive index  1.7000 (estimate)
storage temp.  2-8°C
solubility  7.9g/l
pka pKa 7.46 (Uncertain)
form  Fine Crystalline Powder
color  White to cream
Water Solubility  0.5 g/L
λmax 271nm(H2O)(lit.)
Merck  14,9366
BRN  112227
InChIKey ZEMGGZBWXRYJHK-UHFFFAOYSA-N
CAS DataBase Reference 141-90-2(CAS DataBase Reference)
NIST Chemistry Reference 2-Thiouracil(141-90-2)
EPA Substance Registry System Thiouracil (141-90-2)
Safety Information
Hazard Codes  Xn,T
Risk Statements  40-45-20/21/22
Safety Statements  36/37-53-45
RIDADR  UN 3077 9/PG III
WGK Germany  3
RTECS  YR1575000
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29335995
Hazardous Substances Data 141-90-2(Hazardous Substances Data)

2-Thiouracil Usage And Synthesis
Chemical Properties white to cream fine crystalline powder
Uses Reagent used in the preparation of Antithyroid agents.
Uses antiviral, thyroid depressant
Definition ChEBI: A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group.
Safety Profile Moderately toxic by ingestion. Human teratogenic effects by unspecified routes: developmental abnormalities of the central nervous system, craniofacial area, and endocrine system. Human reproductive effects by unspecified route: effects on newborn, including viabllity index changes. Experimental teratogenic effects. Other experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used in the treatment of hyperthyroidism, angina pectoris, and congestive heart failure. See also MERCAPTANS and KETONES.
Purification Methods Crystallise 2-thiouracil from water or EtOH. [Beilstein 24 H 323, 24 I 315, 24 II 171, 24 III/IV 1237.]

2-Thiouracil Usage And Synthesis
Chemical Properties white to cream fine crystalline powder
Uses Reagent used in the preparation of Antithyroid agents.
Uses antiviral, thyroid depressant
Definition ChEBI: A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group.
Safety Profile Moderately toxic by ingestion. Human teratogenic effects by unspecified routes: developmental abnormalities of the central nervous system, craniofacial area, and endocrine system. Human reproductive effects by unspecified route: effects on newborn, including viabllity index changes. Experimental teratogenic effects. Other experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used in the treatment of hyperthyroidism, angina pectoris, and congestive heart failure. See also MERCAPTANS and KETONES.
Purification Methods Crystallise 2-thiouracil from water or EtOH. [Beilstein 24 H 323, 24 I 315, 24 II 171, 24 III/IV 1237.]