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TIANFU-CHEM 123948-87-8 Topotecan CAS NO.123948-87-8
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T,
- Product Details
Keywords
- 123948-87-8
- Topotecan
- C23H23N3O5
Quick Details
- ProName: TIANFU-CHEM 123948-87-8 Topotecan
- CasNo: 123948-87-8
- Molecular Formula: C23H23N3O5
- Appearance: conform
- Application: 123948-87-8
- DeliveryTime: within 7 days after PO
- PackAge: normal package
- Port: any port in china
- ProductionCapacity: 1 Metric Ton/Day
- Purity: 99%
- Storage: conform
- Transportation: by air
- LimitNum: 1 Kilogram
- Grade: Industrial Grade,Food Grade,Pharma Gra...
Superiority
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:
1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
Our advantage:
1. Higest quality and good package
2.Fast delivery
3.Better payment term
4.Fast response to customer within 6 hours
5.Good business credit in Europe ,US ,Japan ,Korea
Anyway ,if you need any chemicals from China ,Henan Tianfu can help you
Details
| Topotecan Basic information |
| Product Name: | Topotecan |
| Synonyms: | hycamptamine;HYDROGEN CHLORIDE, BUTANOL REAGENT;HYDROGEN CHLORIDE GAS;HYDROGEN CHLORIDE, METHANOL REAGENT;HYDROGEN CHLORIDE, METHANOL REAGENT 10;HYDROGEN CHLORIDE, METHANOL REAGENT 5;HYDROCHLORIC ACID,1.1M;HYDROCHLORIC ACID, 1N |
| CAS: | 123948-87-8 |
| MF: | C23H23N3O5 |
| MW: | 421.45 |
| EINECS: | 231-595-7 |
| Product Categories: | APIs;API |
| Mol File: | 123948-87-8.mol |
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| Topotecan Chemical Properties |
| mp | −114 °C(lit.) |
| bp | >100 °C(lit.) |
| density | 1.2 g/mL at 25 °C(lit.) |
| vapor density | 1.3 (vs air) |
| vapor pressure | 613 psi ( 21.1 °C) |
| Fp | 12 °C |
| storage temp. | 2-8°C |
| solubility | H2O: soluble |
| form | liquid |
| CAS DataBase Reference | 123948-87-8(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T,C,F,Xi |
| Risk Statements | 36/37/38-67-35-20-11-34-48-46-36 |
| Safety Statements | 26-45-36/37/39-37/39-36-22-24/25-16-7 |
| RIDADR | UN 3286 3/PG 2 |
| WGK Germany | 2 |
| RTECS | MW4025000 |
| F | 3 |
| HazardClass | 8 |
| PackingGroup | II |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ALFA | English |
| Topotecan Usage And Synthesis |
| Camptothecin anticancer drugs |
Camptothecin anticancer drugs are alkaloids or derivatives of them after the structure transformation raised from deciduous plant Davidia involucrata Camptotheca acuminate seed or root bark. Clinical application of them mainly includes camptothecin,hydroxycamptothecin, topotecan and irinotecan. Topotecan is a water-soluble semi-synthetic derivative of camptothecin,it is a topoisomerase I inhibitor, inhibiting DNA single strand DNA scission reconnect to damage DNA, its cytotoxicity occurs in cancer cell division S phase, it is an s phase cell cycle specific drug . In vivo it is a two-compartment model,it can be quickly distributed to the liver, kidneys and other parts , of a single intravenous infusion 1.5mg / m2 every 30 minutes , t1 / 2αis 4.1 to 8.1 minutes, plasma protein binding rate is 6.6% ~ 21.3%,it can go into the cerebrospinal fluid. Most of it is excreted by the kidneys, a small part of it is excreted by the bile, within 12 hours, 90% of it is excreted.Clearance rate of renal dysfunction decreases.it is clinically used for the treatment of small cell lung cancer (SCLC), and advanced ovarian cancer, because it can penetrate the blood-brain barrier ,it has a certain effect on the central nervous system cancer and brain metastases. Usage: every single drug dose 1.2mg / m2 intravenous infusion once a day, once every 5 days, 21 days is 1 cycle, there is the need to reduce the dose when in combination with other anticancer drugs. The main adverse events are hematologic toxicity, white blood cells, platelets and hemoglobin decrease; non-hematologic toxicity adverse events are loss of appetite, nausea, vomiting, hair loss, stomatitis, diarrhea, headache, fever, constipation, transient elevated transaminase; occasionally breathing difficulties, hematuria, andelectrocardiogram abnormalities. Severe bone marrow suppression are hanged. Monitor the blood and adjust the dose in accordance with changes in blood during the treatment , if necessary, granulocyte colony stimulating factor (G-CSF), and transfusion of blood components may be given . The above information is edited by the chemicalbook of Tian Ye. |
| Application | Anti-cancer drugs.It can be used alone for the treatment of initially or continuously ineffective chemotherapy metastatic ovarian cancer. |
| Production methods | Compound (I) with 37% formaldehyde and 40% dimethylamine,after aminomethylation in acetic acid, produces the product. |
| Chemical Properties | Off-white Cryst |
| Usage | antineoplastic;DNA topoisomerase type 1 inhibitor |
| Topotecan Preparation Products And Raw materials |
| Raw materials | Dimethylamine |