China (Mainland)
Assessedsupplier
(2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol - CAS NO.123318-82-1
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T,
- Product Details
Keywords
- (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol
- (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol
- 123318-82-1
Quick Details
- ProName: (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-b...
- CasNo: 123318-82-1
- Molecular Formula: C10H11ClFN8O3
- Appearance: White to offwhite crystalline powder
- Application: Intermediate
- DeliveryTime: depends on yr quantity
- PackAge: Fluorinated botte, drums or woven bags...
- Port: china mian port
- ProductionCapacity: 100 Metric Ton/Year
- Purity: 98% min
- Storage: N/A
- Transportation: ---
- LimitNum: 1 Kilogram
Superiority
| (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol | |
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Chemical Name : (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol
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CAS: 123318-82-1
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Molecular formula:
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C10H11ClFN8O3 |
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Molecular weight: 303.68
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Useing:
Be used to manufacture Antitumour medicine |
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Details
Clofarabine Basic information
| Product Name: | Clofarabine |
| Synonyms: | 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE;5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol;CLOFARABINE;CAFDA;2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine;Clolar |
| CAS: | 123318-82-1 |
| MF: | C10H11ClFN5O3 |
| MW: | 303.68 |
| EINECS: | |
| Product Categories: | Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Bases & Related Reagents;Nucleotides;Pharmaceutical intermediate;CLOLAR;Antineoplastic;Anti-cancer&immunity |
| Mol File: | 123318-82-1.mol |
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| Clofarabine Chemical Properties |
| mp | 228-2310C |
| storage temp. | Desiccate at +4°C |
| CAS DataBase Reference | 123318-82-1(CAS DataBase Reference) |
| Clofarabine Usage And Synthesis |
| Chemical Properties | White Solid |
| Usage | ISecond generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic |
| Biological Activity | Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- α and - ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors. |