Product Name: Mivacurium chloride
Synonyms: MIVACURIUM CHLORIDE;rac Mivacurium Chloride;rac-BW-B 1090;rac-Mivacron;rel-(1R,1'R)-2,2'-[[(4E)-1,8-Dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]- isoquinolinium Chloride;[R-[R*,R*-(E)]]2,2'-(1,8-Dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)isoquinolinium] dichloride;Mivacurium Chloride (Mixture of Diastereomers);rac-BW-B 1090U
CAS: 106861-44-3
MF: C58H80Cl2N2O14
MW: 1100.17
EINECS: 643-006-4
Product Categories: Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
Mol File: 106861-44-3.mol
Mivacurium chloride Structure
Mivacurium chloride Chemical Properties
alpha  20D -62.7° (c = 1.9 in water)
storage temp.  Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Safety Information
MSDS Information
Mivacurium chloride Usage And Synthesis
Description Mivacurium chloride,a mixture of three stereoisomers, is an intravenously administered, short-acting skeletal muscle relaxant introduced as an adjunct to general anesthesia. Structurally mivacurium chloride is closely related to doxacurium chloride introduced in 1991 by Wellcome as a muscle relaxant. It is a nondepolarizing neuromuscular blocking agent reportedly with a shorter duration of action and a more rapid rate of spontaneous recovery than other nondepolarizing agents. In extensive clinical trials mivacurium chloride was well tolerated with few side effects.
Chemical Properties Off-White Solid
Originator Wellcome (United Kingdom)
Uses Non-depolarizing neuromuscular blocking agent. Muscle relaxant (skeletal)
Brand name Mivacron (Abbott).
Biological Functions Mivacurium chloride (Mivacron) is a newer agent that is chemically related to atracurium. The primary mechanism of inactivation is hydrolysis by plasma cholinesterase. Although it is useful for patients with renal or hepatic disease, some caution is warranted, since these individuals may have reduced plasma cholinesterase as a result of the disease.Mivacurium has an onset of action (1.8 minutes) and duration of effect (20 minutes) only twice that of succinylcholine, and in this respect, it is the most similar to succinylcholine of all of the nondepolarizing agents.
General Description Mivacurium chloride, 1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, (E)-4-octandioate (Mivacron), is a mixture of three stereoisomers,the trans-trans, cis-trans, and cis-cis diesters, each ofwhich has neuromuscular blocking properties. The cis-cisisomer is about one tenth as potent as the other isomers.Mivacurium chloride is a short-acting nondepolarizing drugused as an adjunct to anesthesia to relax skeletal muscle.The drug is hydrolyzed by plasma esterases, and it is likelythat anticholinesterase agents used as antidotes could prolongrather than reverse the effects of the drug.