China (Mainland)
Assessedsupplier
C40H53N7O5S2 Cobicistat 1004316-88-4 CAS NO.1004316-88-4
- Min.Order: 1 Metric Ton
- Payment Terms: L/C,T/T,
- Product Details
Keywords
- Cobicistat
- 1004316-88-4
- C40H53N7O5S2
Quick Details
- ProName: C40H53N7O5S2 Cobicistat 1004316-...
- CasNo: 1004316-88-4
- Molecular Formula: C40H53N7O5S2
- Appearance: Powder
- Application: 1004316-88-4
- DeliveryTime: by air
- PackAge: Aluminium Foil Bag and Paper Drum
- Port: Any port of China
- ProductionCapacity: 100 Metric Ton/Day
- Purity: 99.5%
- Storage: 1MT
- Transportation: By Sea/Air/DHL
- LimitNum: 1 Metric Ton
- Grade: Industrial Grade,Food Grade,Pharma Gra...
Superiority
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:
1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
Our advantage:
1. Higest quality and good package
2.Fast delivery
3.Better payment term
4.Fast response to customer within 6 hours
5.Good business credit in Europe ,US ,Japan ,Korea
Anyway ,if you need any chemicals from China ,Henan Tianfu can help you
Details
| Cobicistat Basic information |
| Product Name: | Cobicistat |
| Synonyms: | Cobicistat;Cobicistat (GS-9350);thiazol-5-ylMethyl (2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)Methyl)-3-Methylureido)-4-MorpholinobutanaMido)-1,6-diphenylhexan-2-ylcarbaMate;GS 9350;GS9350;GS-9350;Cobicistat D8;(3R,6R,9S)-12-Methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid 5-thiazolylmethyl ester |
| CAS: | 1004316-88-4 |
| MF: | C40H53N7O5S2 |
| MW: | 776.02272 |
| EINECS: | |
| Product Categories: | Inhibitor;Inhibitors |
| Mol File: | 1004316-88-4.mol |
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| Cobicistat Chemical Properties |
| density | 1.228±0.06 g/cm3 (20 ºC 760 Torr) |
| Safety Information |
| Cobicistat Usage And Synthesis |
| Description | Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
| In vitro | Cobicistat (GS-9350) is a potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes as a pharmacoenhancer. GS-9350 inhibits CYP3A with IC50 spectrum from 30 nM to 285 nM. In contrast to ritonavir, GS-9350 is devoid of anti-HIV activity, with IC50 of > 30μM against HIV-1 protease and EC50 of > 30μM in MT-2 HIV infection assay, and is thus more suitable for use in boosting anti-HIV drugs without risking selection of potential drug-resistant HIV variants. GS-9350 shows reduced liability for drug interactions and may have potential improvements in tolerability over ritonavir. |
| Uses | Cobicistat is a HIV protease inhibitor and have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations. |
| Uses | Isotope labelled analogue of Cobicistat (C633150), a HIV protease inhibitor and have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations. |
| Uses | Antiretroviral;Labeled Cobicistat, intended for use as an internal standard for the quantification of Cobicistat by GC- or LC-mass spectrometry. |