CAS 1421373-66-1 Osimertinib mesylate CAS NO.1421373-66-1

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Min.Order: 1 Kilogram
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Product Details

Keywords

1421373-66-1
Osimertinib mesylate
C29H37N7O5S

Quick Details

ProName: CAS 1421373-66-1 Osimertinib mesylate
CasNo: 1421373-66-1
Molecular Formula: C29H37N7O5S
Appearance: white powder
Application: pharma
DeliveryTime: prompt
PackAge: as clients needs
Port: Shanghai,QingdaoTianjin,Guangzhou
ProductionCapacity: 1 Metric Ton/Day
Purity: 99%
Storage: RT
Transportation: sea
LimitNum: 1 Kilogram
Moisture Content: N/A
Impurity: N/A
N/A: N/A

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Details

Osimertinib mesylate Basic information

Product Name: Osimertinib mesylate

Synonyms: Mesylate-AZD9291;Osimertinib Mesylate (Tagrisso, Mereletinib, AZD-9291);Osimertinib d6;N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate;Osimertinib methanesulfonate;Osimertinib (AZD9291) mesylate;AZD-9291 mesylate (Osimertinib mesylate;AZD-9291 mesylate (Osimertinib,Mereletinib)

CAS: 1421373-66-1

MF: C29H37N7O5S

MW: 595.71298

EINECS:

Product Categories: AZD09

Mol File: 1421373-66-1.mol

Osimertinib mesylate Structure

Osimertinib mesylate Chemical Properties

Safety Information

HS Code 29339900

MSDS Information

Osimertinib mesylate Usage And Synthesis

Definition ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of osimertinib and methanesulfonic acid. Used for treatment of EGFR T790M mutation positive non-small cell lung cancer.

Indications The collection of ibrutinib (Imbruvica(R), Pharmacyclics Inc.), afatinib, and osimertinib represents the small, yet expanding, group of covalent SMKIs. Ibrutinib is a non-receptor Bruton’s tyrosine kinase inhibitor approved for the treatment of relapsed chronic lymphocytic leukemia. Afatinib, approved for NSCLC in 2013 and squamous NSCLC in 2016, is a second-generation irreversible EGFR inhibitor that targets wild-type EGFR, the mutant T790M EGFR, and HER2. Osimertinib (AZD9291), which was approved by FDA in November 2015, is a third-generation irreversible EGFR inhibitor that selectively targets the mutant T790M EGFR. Rociletinib, which shares a high degree of structural similarity with that of osimertinib, is a promising covalent EGFR inhibitor developed by Clovis Oncology aimed for the treatment of patients with EGFR T790M-mutated NSCLC, until the company terminated its development in May 2016 following a negative vote fromthe FDA’sOncologic Drugs Advisory Committee.