Product Name: 4-Methylpyrazole
Synonyms: 4-Methyl-1H-pyrazol;1H-Pyrazole, 4-methyl-;4-Methyl-1H-pyrazole;4-Methylpyrazol;4-methyl-pyrazol;Pyrazole, 4-methyl-;4-METHYLPYRRAZOLE;4-METHYLPYRAZOLE
CAS: 7554-65-6
MF: C4H6N2
MW: 82.1
EINECS: 231-445-0
Product Categories: Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Bioactive Small Molecules;Building Blocks;C3 to C5;Cell Biology;Chemical Synthesis;F;Heterocyclic Building Blocks;Pyrazoles
Mol File: 7554-65-6.mol

4-Methylpyrazole Chemical Properties
Melting point  13°C
Boiling point  99-100 °C6 mm Hg(lit.)
density  0.993 g/mL at 25 °C(lit.)
refractive index  n20/D 1.495(lit.)
Fp  205 °F
storage temp.  2-8°C
solubility  soluble
pka 14.95±0.50(Predicted)
form  Liquid After Melting
color  Clear colorless to yellow
Specific Gravity 0.993
Water Solubility  soluble
Sensitive  Hygroscopic
Merck  14,4226
BRN  105204
CAS DataBase Reference 7554-65-6(CAS DataBase Reference)
NIST Chemistry Reference 4-methylpyrazole(7554-65-6)
Safety Information
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36-24/25
RIDADR  2810
WGK Germany  3
RTECS  UQ7350000
F  10-23
HazardClass  6.1(b)
PackingGroup  III
HS Code  29331990
Toxicity LD50 (7 days) in mice, rats (mmol/kg): 3.8, 3.8 i.v.; 7.8, 6.5 orally (Magnusson)

4-Methylpyrazole Usage And Synthesis
Description Fomepizole is the first drug indicated as an antidote for ethylene glycol poisoning (it has also shown promise as a treatment for methanol poisoning). Fomepizole is 4-methyl-1H-pyrazole active as a synthetic alcohol dehydrogenase inhibitor, blocking the formation of toxic ethylene glycol metabolites which are responsible for a severe metabolic acidosis and renal failure. In limited human studies, it reversed the toxicity of potentially lethal doses of ethylene glycol. The main urinary metabolite has been reported to be 4-carboxypyrazole by oxidation of the methyl group. Compared with the current treatment (ethanol), the duration of action is longer and the safety is improved, with no toxic effects reported.
Chemical Properties clear colourless to yellowish liquid after melting
Originator Orphan Medical (US)
Uses Useful as an antidote in methanol and ethylene glycol poisoning.
Uses Antidote in methanol or ethylene glycol poisoning;Alcohol dehydrogenase inhibitor
Uses antidote to ethylene glycol or methanol poisoning
Definition ChEBI: A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.

Product Name: 4-Methylpyrazole
Synonyms: 4-Methyl-1H-pyrazol;1H-Pyrazole, 4-methyl-;4-Methyl-1H-pyrazole;4-Methylpyrazol;4-methyl-pyrazol;Pyrazole, 4-methyl-;4-METHYLPYRRAZOLE;4-METHYLPYRAZOLE
CAS: 7554-65-6
MF: C4H6N2
MW: 82.1
EINECS: 231-445-0
Product Categories: Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Bioactive Small Molecules;Building Blocks;C3 to C5;Cell Biology;Chemical Synthesis;F;Heterocyclic Building Blocks;Pyrazoles
Mol File: 7554-65-6.mol

4-Methylpyrazole Chemical Properties
Melting point  13°C
Boiling point  99-100 °C6 mm Hg(lit.)
density  0.993 g/mL at 25 °C(lit.)
refractive index  n20/D 1.495(lit.)
Fp  205 °F
storage temp.  2-8°C
solubility  soluble
pka 14.95±0.50(Predicted)
form  Liquid After Melting
color  Clear colorless to yellow
Specific Gravity 0.993
Water Solubility  soluble
Sensitive  Hygroscopic
Merck  14,4226
BRN  105204
CAS DataBase Reference 7554-65-6(CAS DataBase Reference)
NIST Chemistry Reference 4-methylpyrazole(7554-65-6)
Safety Information
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36-24/25
RIDADR  2810
WGK Germany  3
RTECS  UQ7350000
F  10-23
HazardClass  6.1(b)
PackingGroup  III
HS Code  29331990
Toxicity LD50 (7 days) in mice, rats (mmol/kg): 3.8, 3.8 i.v.; 7.8, 6.5 orally (Magnusson)

4-Methylpyrazole Usage And Synthesis
Description Fomepizole is the first drug indicated as an antidote for ethylene glycol poisoning (it has also shown promise as a treatment for methanol poisoning). Fomepizole is 4-methyl-1H-pyrazole active as a synthetic alcohol dehydrogenase inhibitor, blocking the formation of toxic ethylene glycol metabolites which are responsible for a severe metabolic acidosis and renal failure. In limited human studies, it reversed the toxicity of potentially lethal doses of ethylene glycol. The main urinary metabolite has been reported to be 4-carboxypyrazole by oxidation of the methyl group. Compared with the current treatment (ethanol), the duration of action is longer and the safety is improved, with no toxic effects reported.
Chemical Properties clear colourless to yellowish liquid after melting
Originator Orphan Medical (US)
Uses Useful as an antidote in methanol and ethylene glycol poisoning.
Uses Antidote in methanol or ethylene glycol poisoning;Alcohol dehydrogenase inhibitor
Uses antidote to ethylene glycol or methanol poisoning
Definition ChEBI: A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.