Product Name: Methylaminoformyl chloride
Synonyms: METHYLCARBAMOYLCHLORIDE;METHYLAMINOFORMYL CHLORIDE;n-methylaminoformyl chloride;Methylcarbamic chloride;N-Methylchloroformamide;Methylcarbamic acid chloride;N-(Chloroformyl)methylamine;N-Methylcarbamoyl chloride
CAS: 6452-47-7
MF: C2H4ClNO
MW: 93.51
EINECS: 229-253-7
Product Categories: Agrochemicals
Mol File: 6452-47-7.mol
Methylaminoformyl chloride Structure
Methylaminoformyl chloride Chemical Properties
Melting point  45°C
Boiling point  93°C (dec.)
density  1.185±0.06 g/cm3(Predicted)
pka 10.67±0.46(Predicted)
CAS DataBase Reference 6452-47-7(CAS DataBase Reference)
Safety Information
Hazard Codes  Xn
Risk Statements  22
MSDS Information
Methylaminoformyl chloride Usage And Synthesis
Description Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.
Uses
Methylaminoformyl chloride can be widely used as an intermediate of carbamate insecticides such as Zhongdingwei, carbofuran, isoprocarb, methomyl, chlorhexidine and carbaryl.
Methylaminoformyl chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.

Preparation
Methylaminoformyl chloride is prepared by reacting methylamine with phosgene. Reaction equation: CH3NH2+COCl2→CH3NHCOCl. A 40% aqueous solution of methylamine is vaporized, and after drying, it is combined with phosgene at a ratio of 1:1.3 (methanol), methylamine at 4 m3/h, and phosgene at a rate of 8.6 m3/h (content 60%-70%). Preheating into the preheater, the preheating temperature of methylamine is controlled at 220-260°C, and the phosgene is controlled at 200-240°C. The preheated two gases enter the test tube and are synthesized at 280-300°C to obtain gaseous methaqualyl chloride. Then, carbon tetrachloride (or chlorobenzene solution) is circulated and absorbed at 0-20°C to obtain a solution of about 10% of carbamoyl chloride (or chlorobenzene), or cooled to a liquid product after 35-40°C or lower[2,3].