Product Name: MEFLOQUINE
Synonyms: MEFLOQUINE;MEFLOQUINE INTERMEDIATE;Mefloquin;Metloquine;(11R,2'S)-Mefloquine;(R)-α-[(2S)-2-Piperidyl]-2,8-bis(trifluoromethyl)-4-quinolinemethanol;(11S,2'R)-Mefloquine;(S)-α-[(2R)-2-Piperidyl]-2,8-bis(trifluoromethyl)-4-quinolinemethanol
CAS: 53230-10-7
MF: C17H16F6N2O
MW: 378.31
EINECS:
Product Categories: Heterocyclic Building Blocks;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals
Mol File: 53230-10-7.mol
MEFLOQUINE Structure
MEFLOQUINE Chemical Properties
Melting point  242-244°C
Boiling point  415.7±40.0 °C(Predicted)
density  1.383±0.06 g/cm3(Predicted)
storage temp.  Refrigerator, Under Inert Atmosphere
pka pKa 8.6 (Uncertain)
CAS DataBase Reference 53230-10-7
Safety Information
MSDS Information
MEFLOQUINE Usage And Synthesis
Pharmacology and mechanism of action Mefloquine is a quinolinemethanol derivative which is structurally related to quinine. It was synthesized and tested by the United States army in the 1960s. The available mefloquine preparation is a racemate with two enantiomers in equal proportions [1]. It was introduced for the treatment of multiresistant P. falciparum in the mid-1980s [2]. In Africa, there are only occasional reports of therapeutic failures, but there has been a rapid development of resistance in the 1990s in parts of Southeast Asia, particularly in Thailand [3]. Cross-resistance with quinine and halofantrine has also been reported [4, 5]. The mechanism of action is not well established. Mefloquine is a schizontocidal drug active against the erythrocytic stages of all species of malaria parasites. It is inactive against exoerythrocytic forms and thus cannot prevent relapse of P. vivax and P. ovale infections [6].