ACEPROMAZINE MALEATE Basic information
Product Name: ACEPROMAZINE MALEATE
Synonyms: 10-(3-(dimethylamino)propyl)phenothiazin-2-ylmethylketonemaleate(1:1);2-acetyl-10-(3-(dimethylamino)propyl)phenothiazine,maleate;2-acetyl-10-(3-(dimethylamino)propyl)-phenothiazinmaleate;aceprome;acetylpromazinemaleate(1:1);anatran;ketone,10-(3-(dimethylamino)propyl)phenothiazin-2-ylmethyl,maleate(1:1);1-[10-[3-(DiMethylaMino)propyl]-10H-phenothiazin-2-yl]ethanone
CAS: 3598-37-6
MF: C23H26N2O5S
MW: 442.53
EINECS: 222-748-9
Product Categories: Aromatics;Heterocycles;Sulfur & Selenium Compounds;POLARAMINE;Intermediates & Fine Chemicals;Pharmaceuticals;Dopamine receptor
Mol File: 3598-37-6.mol

ACEPROMAZINE MALEATE Chemical Properties
Melting point  135-136°C
storage temp.  -20°C Freezer
solubility  H2O: >10mg/mL
pka 9.3(at 25℃)
form  powder
color  yellow
Safety Information
Hazard Codes  Xn,N,T
Risk Statements  22-50/53-20/21/22-43-36/37/38-23/24/25
Safety Statements  60-61-36/37/39-26-22-45
RIDADR  UN 3077
WGK Germany  2
RTECS  2664-15-5
HS Code  2934302300
Toxicity LD50 orally in rats: 400 mg/kg; i.v. in mice: 59 mg/kg (Wirth)

ACEPROMAZINE MALEATE Usage And Synthesis
Chemical Properties Yellow Crystalline Solid
Uses A tranquilizer
Uses antihistamine
Uses vitamin D2 analog, blood calcium regulator, therapeutc for chronic hypocalcemia
Safety Profile Poison by ingestion, subcutaneous,and intravenous routes. When heated to decomposition itemits highly toxic fumes of NOx and SOx.
Veterinary Drugs and Treatments Acepromazine is approved for use in dogs, cats, and horses. Labeled indications for dogs and cats include: “. . . as an aid in controlling intractable animals . . . alleviate itching as a result of skin irritation; as an antiemetic to control vomiting associated with motion sickness” and as a preanesthetic agent. The use of acepromazine as a sedative/tranquilizer in the treatment of adverse behaviors in dogs or cats has largely been supplanted by newer, effective agents that have fewer adverse effects. Its use for sedation during travel is controversial and many no longer recommend drug therapy for this purpose.
In horses, acepromazine is labeled “. . . as an aid in controlling fractious animals,” and in conjunction with local anesthesia for various procedures and treatments. It is also commonly used in horses as a pre-anesthetic agent at very small doses to help control behavior.
Although not approved, it is used as a tranquilizer (see doses) in other species such as swine, cattle, rabbits, sheep and goats. Acepromazine has also been shown to reduce the incidence of halothane- induced malignant hyperthermia in susceptible pigs.