Product Name: Naproxen sodium
Synonyms: apranax;l-(-)-6-methoxy-alpha-methyl-2-naphthaleneaceticacidsodiumsalt;naprosynsodium;sodiumnaprosyn;sodiumnaproxen;6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETIC ACID SODIUM;(S)-6-METHOXY-A-METHYL-2-NAPHTHALENEACETIC ACID, SODIUM SALT;(S)-6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETIC ACID SODIUM SALT
CAS: 26159-34-2
MF: C14H13O3.Na
MW: 252.24
EINECS: 247-486-2
Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Anaprox, Naprelan;Other APIs;Chemical
Mol File: 26159-34-2.mol

Naproxen sodium Chemical Properties
Melting point  250-251°C
alpha  D -11° (in methanol)
storage temp.  Desiccate at RT
solubility  Freely soluble in water, freely soluble or soluble in methanol, sparingly soluble in ethanol (96 per cent).
form  neat
Water Solubility  Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water.
CAS DataBase Reference 26159-34-2(CAS DataBase Reference)
Safety Information
Hazard Codes  Xn,T
Risk Statements  22-61
Safety Statements  53-45
RIDADR  3249
WGK Germany  3
RTECS  QJ1047000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2918992090

Naproxen sodium Usage And Synthesis
Non-steroidal anti-inflammatory analgesic Naproxen sodium is a non-steroidal anti-inflammatory analgesic drug which is more tolerable to human, belonging to the phenylpropionic acid compounds. It plays anti-inflammatory effect by inhibiting prostaglandin synthesis.It is absorbed rapidly after oral administration and the plasma reached the peak concentration within 2 to 4 hours. Food has little effect on the rate of absorption. Naproxen and plasma protein are highly binded(99%); the plasma concentration is between 23~40mcg/ml. The metabolic process is demethylation and then combining with glucuronide; the elimination half-life is 12 to 15 hours, mainly excreted by the urine. Clinical application is to relieve a variety of mild to moderate degree of pain, such as tooth extraction and other postoperative pain, primary dysmenorrhea and headache. It is also used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendinitis, bursitis and acute gouty arthritis; it also plays a role in arthritis pain, swelling and activity restricted symptom. Psoriatic arthritis and Reiter's syndrome can also be treated with this product. Compared with ibuprofen, fenoprofen, aspirin, sulindac and indomethacin, the symptom relief effect was similar, but the incidence and severity of adverse reactions in the gastrointestinal and neurological systems were low. In addition, this product is also the same as aspirin which can inhibit platelet aggregation and prolong bleeding time; but the effect is reversible, and can be restored after stopping.
Naproxen sodium and plasma protein binding rate is high (99%), and other protein-binding drugs can be replaced by its joint out. Therefore, the acceptance of these drugs (such as oral anticoagulants, sulfonylurea, hydantoins) people should observe the interaction effects. At the same time the application of probenecid, naproxen can increase the plasma concentration, half-life period. Magnesium hydroxide, aluminum can make this product absorption rate slightly lower; sodium bicarbonate can make it higher.
Uses Used as anti-inflammatory analgesic
Chemical Properties White Powder
Uses Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively
Uses An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory
Definition ChEBI: The sodium salt of naproxen.
Brand name Aleve (Bayer); Anaprox (Roche);Naprelan (Stat Trade).
Biological Activity Non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress.
Naproxen sodium Preparation Products And Raw materials
Raw materials Naproxen