Product Name: Oxaprozin
Synonyms: 4,5-Diphenyl-2-oxazolepropanoic acid, Daypro;2-Oxazolepropanoic acid, 4,5-diphenyl-;Durapro;Oxapro;4,5-Diphenyloxazole-2-propionic acid;Alvo;4,5-Diphenyl-2-oxazolepropanoicacid\Oxaprozin;Oxaprozin,4,5-Diphenyl-2-oxazolepropanoic acid, Daypro
CAS: 21256-18-8
MF: C18H15NO3
MW: 293.32
EINECS: 244-296-1
Product Categories: Oxazoles, Isoxazoles & Benzoxazoles;ALINIA;Carboxylic Acids;Oxazoles, Isoxazoles & Benzoxazoles;APIs;Carboxylic Acids
Mol File: 21256-18-8.molOxaprozin Chemical Properties

Melting point  154 °C
Boiling point  435.17°C (rough estimate)
density  1.2278 (rough estimate)
refractive index  1.5100 (estimate)
pka 4.3(at 25℃)
form  solid
color  Crystals from methanol
Water Solubility  4mg/L(37 ºC)
Merck  14,6924
InChIKey OFPXSFXSNFPTHF-UHFFFAOYSA-N
CAS DataBase Reference 21256-18-8(CAS DataBase Reference)
EPA Substance Registry System 2-Oxazolepropanoic acid, 4,5-diphenyl- (21256-18-8)

Safety Information
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  24/25-36/37/39-36-26
WGK Germany  3
RTECS  RP6990000
Hazard Note  Irritant
HS Code  29349990
Hazardous Substances Data 21256-18-8(Hazardous Substances Data)
Toxicity TDLo orl-rbt: 39 mg/kg (female 6-18D post):TER IYKEDH 15,250,84

Oxaprozin Usage And Synthesis
Abstract Oxaprozin, also known as Oxaprozinum, (sold under the names: Daypro, Dayrun, Duraprox) is a non-steroidal anti-inflammatory drug (NSAID),used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. Chemically, it is a propionic acid derivative.NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.
Taboo This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.
Heart disease risk. Oxaprozin belongs to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may increase your risk of heart-related diseases, such as heart attack, heart failure, and stroke. Your risk may be higher if you’re taking it long term, at high doses, or if you already have heart problems or risk factors for heart disease, such as high blood pressure.
May cause ulcers and stomach bleeding. Oxaprozin can cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may not cause symptoms. Smoking cigarettes or drinking alcohol can make these conditions worse.
Coronary artery bypass graft surgery. Oxaprozin shouldn’t be used for pain after coronary artery bypass graft surgery. Taking it could increase your risk for a heart attack or stroke.