Product Name: Doxycycline hydrochloride
Synonyms: VIBRAMYCIN, HCL;,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride;biocamycin;doxigalumicina;doxy-ii;doxy-tablinen;ecodox;hydramycin
CAS: 10592-13-9
MF: C22H25ClN2O8
MW: 480.9
EINECS: 234-198-7
Product Categories: Antibiotic Explorer;Peptide Synthesis/Antibiotics;Antibiotics
Mol File: 10592-13-9.mol

Doxycycline hydrochloride Chemical Properties
Melting point  195-201℃
Fp  87℃
storage temp.  0-6°C
solubility  H2O: 50 mg/mL, clear, yellow-green
form  powder
color  yellow
Water Solubility  Soluble in water.
CAS DataBase Reference 10592-13-9(CAS DataBase Reference)
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36/37
RIDADR  NA 1993 / PGIII
WGK Germany  3
F  8
HS Code  29413000Doxycycline hydrochloride Usage And Synthesis

Overview Doxycycline hydrochloride is the hydrochloride form of doxycycline, being a tetracycline antibiotic that has enjoyed widespread use in both veterinary and human medicine owing to its relatively broad spectrum and wide margin of safety. The first members of the tetracycline class were isolated from several species of bacteria from the genus Streptomyces in the1940s and 1950s. Since that time, a variety of tetracycline have been discovered, both naturally produced (e.g., chlortetracycline) and semisynthetic (e.g., doxycycline and tetracycline). Doxycycline was discovered in 1967 and has undergone extensive investigation, both for its antimicrobial properties as well as the effects it has on the physiology of higher organisms[1].
Globally, doxycycline has remained one of the most commonly used and inexpensive of the broad-spectrum antibiotic drugs currently in use[2]. In Australia, over the period 2002–2005, there were still well over 800,000 prescriptions of doxycycline 100 mg annually[3]. The development of doxycycline in 1967 followed the development of tetracycline class of compounds and their clinical application in 1953[4]. It has also been observed that it has been prescribed up to three times as often as minocycline, another commonly used drug in the tetracycline class[4]. Doxycycline has a variety of applications, but it is known that the tetracycline class of antibiotics does have a range of side-effects and noteworthy contraindications[2].
Two different commercial doxycycline products are available for use in dogs; doxycycline hyclate tablets (Ronaxan; Merial) are available in several European countries, and doxycycline monohydrate paste or tablets (VibraVet; Pfizer) are available in other countries, including Australia, New Zealand, and South Africa. These products are used for treatment of respiratory tract infections and other infections caused by a variety of bacteria, including staphylococci.

Product Name: Doxycycline hydrochloride
Synonyms: VIBRAMYCIN, HCL;,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride;biocamycin;doxigalumicina;doxy-ii;doxy-tablinen;ecodox;hydramycin
CAS: 10592-13-9
MF: C22H25ClN2O8
MW: 480.9
EINECS: 234-198-7
Product Categories: Antibiotic Explorer;Peptide Synthesis/Antibiotics;Antibiotics
Mol File: 10592-13-9.mol

Doxycycline hydrochloride Chemical Properties
Melting point  195-201℃
Fp  87℃
storage temp.  0-6°C
solubility  H2O: 50 mg/mL, clear, yellow-green
form  powder
color  yellow
Water Solubility  Soluble in water.
CAS DataBase Reference 10592-13-9(CAS DataBase Reference)
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36/37
RIDADR  NA 1993 / PGIII
WGK Germany  3
F  8
HS Code  29413000Doxycycline hydrochloride Usage And Synthesis

Overview Doxycycline hydrochloride is the hydrochloride form of doxycycline, being a tetracycline antibiotic that has enjoyed widespread use in both veterinary and human medicine owing to its relatively broad spectrum and wide margin of safety. The first members of the tetracycline class were isolated from several species of bacteria from the genus Streptomyces in the1940s and 1950s. Since that time, a variety of tetracycline have been discovered, both naturally produced (e.g., chlortetracycline) and semisynthetic (e.g., doxycycline and tetracycline). Doxycycline was discovered in 1967 and has undergone extensive investigation, both for its antimicrobial properties as well as the effects it has on the physiology of higher organisms[1].
Globally, doxycycline has remained one of the most commonly used and inexpensive of the broad-spectrum antibiotic drugs currently in use[2]. In Australia, over the period 2002–2005, there were still well over 800,000 prescriptions of doxycycline 100 mg annually[3]. The development of doxycycline in 1967 followed the development of tetracycline class of compounds and their clinical application in 1953[4]. It has also been observed that it has been prescribed up to three times as often as minocycline, another commonly used drug in the tetracycline class[4]. Doxycycline has a variety of applications, but it is known that the tetracycline class of antibiotics does have a range of side-effects and noteworthy contraindications[2].
Two different commercial doxycycline products are available for use in dogs; doxycycline hyclate tablets (Ronaxan; Merial) are available in several European countries, and doxycycline monohydrate paste or tablets (VibraVet; Pfizer) are available in other countries, including Australia, New Zealand, and South Africa. These products are used for treatment of respiratory tract infections and other infections caused by a variety of bacteria, including staphylococci.