Product Name: p-Toluenesulfonic acid
Synonyms: Tenofovirdisoproxil Impurity 41;P-TOLUENESULFONIC ACID;PTS ACID;P-TOLUENE SULPHONIC ACID;TSA-65IP;TSA-65M;TSA-65W;TSA-95
CAS: 104-15-4
MF: C7H8O3S
MW: 172.2
EINECS: 203-180-0
Product Categories: curing agent;FINE Chemical & INTERMEDIATES;Organics
Mol File: 104-15-4.mol

p-Toluenesulfonic acid Chemical Properties
Melting point  106~107℃
Boiling point  116 °C
density  1.07
refractive index  1.3825-1.3845
Fp  41 °C
storage temp.  Flammables area
pka -0.43±0.50(Predicted)
form  Solution
color  Clear colorless to light yellow
Water Solubility  soluble
CAS DataBase Reference 104-15-4(CAS DataBase Reference)
NIST Chemistry Reference P-toluene sulfonic acid(104-15-4)
EPA Substance Registry System 4-Methylbenzenesulfonic acid (104-15-4)
Safety Information
Hazard Codes  C
Risk Statements  34-10
Safety Statements  45-26-23
RIDADR  2585
HazardClass  8
PackingGroup  III
HS Code  29163990
Hazardous Substances Data 104-15-4(Hazardous Substances Data)

p-Toluenesulfonic acid Usage And Synthesis
Overview p-toluene sulfonic acid (Its molecular structural formula is p-CH3C6H4SO3H, also known as TsOH, English name is p-toluene sulfonic acid) referred to as PTS, is a non-oxidizing organic acid, white needle or powder crystals, soluble in water, alcohols, ethers and other polar solvents. Easy deliquescence, easy to make wood, cotton fabric dehydration and carbonization, insoluble in benzene and toluene. generating p-cresol when alkali fusion. Commonly, p-toluenesulfonic acid-monohydrate (TsOHH2O) or tetrahydrate (TsOH4H2O) is preferred.
Preparation of methyl p-cresol acid in industry is by using concentrated sulfuric acid on the toluene sulfonation of p-toluenesulfonic acid. The preparated p-toluenesulfonic acid often contains benzene sulfonic acid and sulfuric acid impurities, can be purified in recrystallization of concentrated hydrochloric acid, azeotropic drying.
p-toluene sulfonic acid is widely used as catalyst agent in the synthesis of pharmaceuticals, pesticides, polymerization stabilizer and organic synthesis (esters, etc.), paint intermediates and resin curing agent. And it is also the commonly used acid catalyst in organic synthesis. It is neutralized with sodium hydroxide and then obtains sodium p-toluene sulfonate, and react with phosphorus pentachloride, can obtains p-toluenesulfonyl chloride. The latter used in the nucleophilic substitution reaction, also used as alcohol hydroxyl protective group. p-CH3C6H4SO3Na + PCl5 →p-CH3C6H4SO2Cl.
The use of p-toluenesulfonic acid also catalyzes the protection of dihydrofuran on the alcohol, carboxylic acid esterification, transesterification reaction, making the aldehyde generate acetal.

Product Name: p-Toluenesulfonic acid
Synonyms: Tenofovirdisoproxil Impurity 41;P-TOLUENESULFONIC ACID;PTS ACID;P-TOLUENE SULPHONIC ACID;TSA-65IP;TSA-65M;TSA-65W;TSA-95
CAS: 104-15-4
MF: C7H8O3S
MW: 172.2
EINECS: 203-180-0
Product Categories: curing agent;FINE Chemical & INTERMEDIATES;Organics
Mol File: 104-15-4.mol

p-Toluenesulfonic acid Chemical Properties
Melting point  106~107℃
Boiling point  116 °C
density  1.07
refractive index  1.3825-1.3845
Fp  41 °C
storage temp.  Flammables area
pka -0.43±0.50(Predicted)
form  Solution
color  Clear colorless to light yellow
Water Solubility  soluble
CAS DataBase Reference 104-15-4(CAS DataBase Reference)
NIST Chemistry Reference P-toluene sulfonic acid(104-15-4)
EPA Substance Registry System 4-Methylbenzenesulfonic acid (104-15-4)
Safety Information
Hazard Codes  C
Risk Statements  34-10
Safety Statements  45-26-23
RIDADR  2585
HazardClass  8
PackingGroup  III
HS Code  29163990
Hazardous Substances Data 104-15-4(Hazardous Substances Data)

p-Toluenesulfonic acid Usage And Synthesis
Overview p-toluene sulfonic acid (Its molecular structural formula is p-CH3C6H4SO3H, also known as TsOH, English name is p-toluene sulfonic acid) referred to as PTS, is a non-oxidizing organic acid, white needle or powder crystals, soluble in water, alcohols, ethers and other polar solvents. Easy deliquescence, easy to make wood, cotton fabric dehydration and carbonization, insoluble in benzene and toluene. generating p-cresol when alkali fusion. Commonly, p-toluenesulfonic acid-monohydrate (TsOHH2O) or tetrahydrate (TsOH4H2O) is preferred.
Preparation of methyl p-cresol acid in industry is by using concentrated sulfuric acid on the toluene sulfonation of p-toluenesulfonic acid. The preparated p-toluenesulfonic acid often contains benzene sulfonic acid and sulfuric acid impurities, can be purified in recrystallization of concentrated hydrochloric acid, azeotropic drying.
p-toluene sulfonic acid is widely used as catalyst agent in the synthesis of pharmaceuticals, pesticides, polymerization stabilizer and organic synthesis (esters, etc.), paint intermediates and resin curing agent. And it is also the commonly used acid catalyst in organic synthesis. It is neutralized with sodium hydroxide and then obtains sodium p-toluene sulfonate, and react with phosphorus pentachloride, can obtains p-toluenesulfonyl chloride. The latter used in the nucleophilic substitution reaction, also used as alcohol hydroxyl protective group. p-CH3C6H4SO3Na + PCl5 →p-CH3C6H4SO2Cl.
The use of p-toluenesulfonic acid also catalyzes the protection of dihydrofuran on the alcohol, carboxylic acid esterification, transesterification reaction, making the aldehyde generate acetal.